Customized Contact Lenses

定制隐形眼镜

• 批准号: 7895512
• 负责人: GEUNYOUNG YOON
• 金额: $ 37.87万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-02 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7895512
• 关键词: Affect; Anterior; Back; Blinking; Clinical; Contact Lenses; Cornea; Defect; Engineering; Exposure to; Eye; Gases; Goals; Grant; Hydrophilic Contact Lenses; Image; Individual; Keratoconus; Knowledge; Lasers; Life; Measures; Movement; Normal Range; Operative Surgical Procedures; Optics; Outcome; Patients; Performance; Positioning Attribute; Progress Reports; Radial; Research; Research Project Grants; Residual state; Rest; Retinal; Rotation; Sclera; Shapes; Stroke; Surface; System; Techniques; Testing; Time; Translations; Vision; Visual; Visual system structure; adaptive optics; advanced disease; base; design; improved; lens; neuroadaptation; prevent; public health relevance; research study; visual performance

DESCRIPTION (provided by applicant): The long range goal of this translational-engineering research project is to improve the vision of people who have abnormal corneal conditions such as keratoconus. In the previous grant period, we developed the ability to measure wavefront error in these eyes and we also developed customized soft corneal contact lenses that can compensate for their extreme higher-order ocular aberrations. Although these customized lenses can produce substantial improvements in visual performance, more needs to be done to restore acuity to normal values. In particular, the benefit was compromised by the unpredictable translation and rotation of the lens on the cornea, and may have been compromised by neural adaptation to the poor retinal image quality before correction. Our efforts during the next grant period are targeted at research that will overcome these limitations. Aim1.1 will stabilize the movement of customized soft contact lenses by sculpting the back surface profile to match the keratoconic anterior surface of cornea. Aim1.2 will optimize correction performance by selecting higher order aberrations to be corrected that have a significant impact on vision but are less sensitive to lens movements. Aim 1.3 will determine significance of the internal optics aberration in keratoconic eyes that cannot be corrected with conventional rigid gas permeable (RGP). Aim1.4 is to develop customized scleral lenses that sit stably on the sclera rather than cornea. Aim 1.5 is to compare the visual outcomes of these new, customized corneal and scleral contact lenses with conventional RGP lenses focusing on enhancing the benefits and reducing the limitations of the customized lenses. Aim 2 will test the hypothesis that patients with keratoconus may not be able to immediately achieve the full benefit of customized correction because of persisting neural adaptation to the poor retinal image quality before correction. Similar neural adaptation has been shown in normal eyes and in patients who have received laser refractive surgery, and we will test the extent of this adaptation in patients who have lived for years with extremely aberrated corneas. Such patients may require a long period of exposure to improved optical quality before reaping the full visual benefit of a customized optical correction. Therefore, we will also use a large-stroke adaptive optics system and customized scleral lenses for experiments on the effects of short- and long-term adaptation to higher order aberrations on perceived retinal image quality in these abnormal corneal patients. PUBLIC HEALTH RELEVANCE: The optical defects (higher order aberrations) induced by irregular shapes of the cornea with keratoconus cause significant degradation in visual quality as the disease advances. Customized contact lenses designed to correct the aberration of individual eyes can provide the patients with substantially improved visual performance.

描述（由申请人提供）：该转化工程研究项目的长期目标是改善患有圆锥角膜等异常角膜疾病的人的视力。在上一个资助期间，我们开发了测量这些眼睛的波前误差的能力，我们还开发了定制的软角膜隐形眼镜，可以补偿其极高阶的眼部像差。尽管这些定制镜片可以显着改善视觉性能，但仍需要做更多工作才能将视力恢复到正常值。特别是，这种好处因晶状体在角膜上不可预测的平移和旋转而受到损害，并且可能因神经适应矫正前较差的视网膜图像质量而受到损害。我们在下一个资助期内的努力目标是克服这些限制的研究。 Aim1.1 将通过雕刻后表面轮廓以匹配角膜的圆锥形前表面来稳定定制软性隐形眼镜的运动。 Aim1.2将通过选择要校正的高阶像差来优化校正性能，这些像差对视力有显着影响，但对镜片移动不太敏感。目标 1.3 将确定圆锥角膜眼内部光学像差的重要性，而传统的刚性透气镜 (RGP) 无法矫正该像差。目标 1.4 是开发定制的巩膜镜片，使其稳定地放置在巩膜而不是角膜上。目标 1.5 是将这些新型定制角膜和巩膜隐形眼镜与传统 RGP 镜片的视觉效果进行比较，重点是增强定制镜片的优点并减少其局限性。目标 2 将检验以下假设：圆锥角膜患者可能无法立即获得定制矫正的全部益处，因为矫正前神经系统持续适应较差的视网膜图像质量。在正常眼睛和接受激光屈光手术的患者中也显示出类似的神经适应，我们将在多年来角膜极度畸变的患者中测试这种适应的程度。此类患者可能需要长时间接触改善的光学质量，才能获得定制光学矫正的全部视觉益处。因此，我们还将使用大行程自适应光学系统和定制巩膜镜片来实验短期和长期适应高阶像差对这些异常角膜患者视网膜图像质量的影响。公众健康相关性：随着疾病的进展，圆锥角膜的角膜不规则形状引起的光学缺陷（高阶像差）会导致视觉质量显着下降。旨在矫正个体眼睛像差的定制隐形眼镜可以为患者提供显着改善的视觉表现。