Customized Contact Lenses

定制隐形眼镜

• 批准号: 6797428
• 负责人: GEUNYOUNG YOON
• 金额: $ 26.7万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-02 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6797428
• 关键词: biomedical equipment development; clinical biomedical equipment; clinical research; contact lens; cornea disorder; diagnosis design /evaluation; eye disorder diagnosis; human subject; human therapy evaluation; keratoconus; keratoplasty; optics; patient oriented research

DESCRIPTION (provided by applicant): Wavefront aberrations in the eye's optics degrade vision. These aberrations, including many higher order aberrations that are not corrected by conventional spectacles, are especially severe in patients with keratoconus and in patients who have had penetrating keratoplasty. Accurate measurement and correction of these higher order aberrations could result in substantial improvements in vision. However, little wave aberration data can be obtained from patients with these conditions, primarily because existing wavefront sensors have too small a dynamic range to measure the large aberrations in these eyes. Moreover, even if measurements were available, there are few available therapeutic alternatives. The research objectives of this bioengineering research project are to develop a robust wavefront sensor, with a large dynamic range, that will reliably diagnose the wave aberrations in highly aberrated eyes, and to develop a customized contact lens that can compensate for most of these aberrations. The key to expanding the dynamic range of the wavefront sensor is the use of a translational plate that increases spacing between wavefront sensing spots. The key to developing the contact lens is the use of high-power laser ablation of the contact lens based on the measurements with the wavefront sensor.

描述(由申请人提供)： 眼睛光学系统中的波前像差会降低视力。这些像差，包括许多传统眼镜无法矫正的高阶像差，在圆锥角膜患者和接受过穿透性角膜移植的患者中尤为严重。对这些高阶像差的准确测量和纠正可能会导致视力的显著改善。然而，从患有这些疾病的患者身上可以获得很少的波像差数据，主要是因为现有的波前传感器的动态范围太小，无法测量这些眼睛的大像差。此外，即使有测量方法，也几乎没有可用的治疗选择。该生物工程研究项目的研究目标是开发一种强大的波前传感器，具有大的动态范围，可以可靠地诊断高度像差眼睛的波像差，并开发一种定制的隐形眼镜，可以补偿大多数这些像差。扩大波前传感器动态范围的关键是使用平移板来增加波前感测点之间的间距。研制隐形眼镜的关键是在波前传感器测量的基础上使用高功率激光烧蚀隐形眼镜。