FAMILIAL FACTORS IN BARRETT'S ESOPHAGUS

巴雷特食管的家族因素

• 批准号: 6634749
• 负责人: AMITABH CHAK
• 金额: $ 13.24万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6634749
• 关键词: Barretts esophagus; adenocarcinoma; endoscopy; family genetics; genetic susceptibility; human subject; longitudinal human study; patient oriented research

DESCRIPTION (provided by applicant) Advances in basic sciences often translate into an increased understanding of disease processes. Similarly, advances in endoscopic engineering also produce new technology with novel applications in clinical gastroenterology. I believe that patient-oriented researchers in gastrointestinal diseases and gastrointestinal endoscopy must translate advances in basic sciences and engineering technology to improved methods for patient care. Using my previous experience in basic research and training in advanced endoscopy, I have initiated and successfully implemented investigations that address this goal. My research objectives have been furthered by the opportunity to mentor several advanced gastroenterology fellows in the performance of specialized endoscopic procedures and patient-oriented research projects. These trainees are now productive clinical investigators in the field of gastrointestinal endoscopy. Protected time provided by this award will permit me to develop a meaningful research program that focuses on applying new endoscopic techniques and advances in human genetics to the evaluation of Barrett's esophagus and esophageal adenocarcinoma. The award will also further my education in two areas in which it is slightly deficient, viz., biostatistics and human genetics. Educational courses in these subjects and collaborations with experts in these fields will strengthen the development of my research program. Lastly, the award will allow me to teach advanced endoscopy to new trainees and mentor them in the development of their own research projects within my program. Esophageal adenocarcinoma is associated with a very poor prognosis. More effective screening, surveillance, and treatment strategies are required. The aim of the current proposal is to identify familial factors involved in the development of Barrett's esophagus and esophageal adenocarcinoma. The ultimate goal of this research program is to help identify the heritable genetic mutation(s) that determine susceptibility to Barrett's esophagus in order to improve screening and surveillance strategies for this disease.

描述（由申请人提供） 基础科学的进步往往转化为对 疾病过程。同样，内窥镜工程的进步也产生了 在临床胃肠病学中具有新应用的新技术。我相信 以病人为导向的研究人员在胃肠道疾病和 胃肠道内窥镜检查必须将基础科学的进步转化为 工程技术，以改善病人护理的方法。使用我以前的 在基础研究和先进的内窥镜培训经验，我有 启动并成功实施了旨在实现这一目标的调查。 我的研究目标得到了进一步的机会，指导几个 高级胃肠病学研究员在专业内窥镜的性能 程序和以病人为导向的研究项目。这些学员现在 胃肠内窥镜检查领域的富有成效的临床研究者。 这个奖项提供的保护时间将允许我发展一个有意义的 研究计划，重点是应用新的内窥镜技术， 人类遗传学在评估Barrett食管方面的进展， 食管腺癌该奖项也将进一步我的教育在两个 有些地方稍有欠缺，即，生物统计学与人类 遗传学这些主题的教育课程和与专家的合作 在这些领域的研究将加强我的研究计划的发展。最后， 该奖项将使我能够向新学员和导师教授先进内窥镜检查术 他们在我的项目中开发自己的研究项目。 食管腺癌预后极差。更 需要有效的筛查、监测和治疗策略。的 目前建议的目的是确定涉及的家庭因素， Barrett食管和食管腺癌的发展。最终 这项研究计划的目标是帮助确定遗传基因， 决定Barrett食管易感性的突变， 改进对这一疾病的筛查和监测战略。