Multi-Microcoil Probes for Capillary NMR Detection

用于毛细管 NMR 检测的多微线圈探针

• 批准号: 6948999
• 负责人: TIMOTHY L PECK
• 金额: $ 35.41万
• 依托单位: PROTASIS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6948999
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; high throughput technology; nuclear magnetic resonance spectroscopy

DESCRIPTION (provided by applicant): The overall goal of this SBIR effort is to commercialize a new family of capillary-scale, high-resolution nuclear magnetic resonance (NMR) spectroscopy flowprobes that employ multiple detection cells in a single probe for high throughput. NMR is utilized extensively by the pharmaceutical and biotechnology industries, but remains one of few analytical methods in which parallel data acquisition has not been applied to increase the number of samples that can be simultaneously evaluated. The reasons behind this are the intrinsically related to the hardware involved in data acquisition. Poor throughput (i.e. relatively long time required for NMR analysis) remains a formidable challenge in drug discovery and development. The company submitting this proposal has a demonstrated track record of using SBIR funding to commercialize novel microcoil (capillary-based) NMR probe technologies. This proposal builds upon the speed and throughput advantages that have been achieved in capillary scale NMR to further advance high throughput screening through multi-sample analysis using a single probe. Technical aspects of both probe design and sample management is addressed. The long-term implications of this technological advance to health and health-related companies, particularly pharmaceutical companies, are significant. The ability to coordinate sample entry, sample exit, and NMR data acquisition for multiple samples in a single magnet/spectrometer/probe system pushes the boundaries of NMR and holds potential to dramatically change the way in which NMR is performed in the future.

描述(由申请人提供)： 这项SBIR工作的总体目标是将一种新的毛细管级、高分辨率核磁共振(核磁共振)波谱流动探头系列商业化，该探头在一个探头中使用多个检测单元，以实现高通量。核磁共振被制药和生物技术行业广泛使用，但仍是为数不多的未应用并行数据采集来增加可同时评估的样品数量的分析方法之一。这背后的原因是与数据采集所涉及的硬件内在联系。产量低(即核磁共振分析所需的时间相对较长)仍然是药物发现和开发中的一个巨大挑战。提交这份提案的公司在使用SBIR资金将新型微线圈(基于毛细管)的核磁共振探测技术商业化方面有着良好的记录。这项建议建立在毛细管规模核磁共振已实现的速度和吞吐量优势的基础上，通过使用单个探针进行多样本分析，进一步推进高通量筛选。讨论了探头设计和样品管理的技术方面。这一技术进步对健康和与健康相关的公司，特别是制药公司的长期影响是重大的。在单个磁体/光谱仪/探头系统中协调多个样品的样品进入、样品退出和核磁共振数据采集的能力打破了核磁共振的界限，并有可能极大地改变未来进行核磁共振的方式。