Multi-microcoil Probes for Capillary Scale NMR Detection

用于毛细管规模 NMR 检测的多微线圈探针

• 批准号: 6403788
• 负责人: TIMOTHY L PECK
• 金额: $ 9.97万
• 依托单位: MAGNETIC RESONANCE MICROSENSORS CORP
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6403788
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; computer program /software; image enhancement; image processing; material; nuclear magnetic resonance spectroscopy; radiowave radiation

DESCRIPTION (Provided by Applicant): The overall goal of this SBIR effort is to develop commercial small-scale high-resolution nuclear magnetic resonance (NMR) spectroscopy probes to increase throughput via the investigation of multiple samples in a single probe. NMR is utilized extensively by the pharmaceutical and biotecimology industries, but remains one of the very few analytical methods in which parallel data acquisition has not been applied to increase the number of samples that can be simultaneously evaluated. The reasons behind this are intrinsically related to the hardware involved in data acquisition. Recent academic results have shown that some of these limitations can be overcome by the use of small micro coils; Many design issues still remain to make such systems compatible with the narrow bore magnets that are predominant in industrial settings. These issues are addressed in this Phase I effort for purposes of feasibility assessment. This serves as the first step in MRM Corporation's plans to commercialize multi-coil probes. PROPOSED COMMERCIAL APPLICATION: The most immediate and obvious potential commercial application is pharmaceutical research, particularly drug discovery. NMR is used extensively in this application area for target analysis, metabolic studies, combinatorial chemistry, and for general structural elucidation. Other industries of application include biotechnology, chemical product research and development, and generally analytical chemical research (government laboratories, universities, etc.)

描述（由申请人提供）：本SBIR工作的总体目标是 开发商用小型高分辨率核磁共振仪 光谱探针，以增加吞吐量，通过研究多个 在一个探针中取样。NMR被广泛用于制药行业。 和生物技术产业，但仍然是为数不多的分析之一， 并行数据采集的方法尚未应用于增加 可以同时评估的样本数量。这背后的原因 本质上与数据采集中涉及的硬件相关。最近 学术研究结果表明，这些限制中的一些可以通过以下方式克服： 使用小的微线圈;许多设计问题仍然存在，以使这种 与窄孔磁体兼容的系统， 工业环境。这些问题在第一阶段工作中得到解决， 可行性评估的目的。这是MRM的第一步 公司计划将多线圈探头商业化。 拟定商业应用： 最直接和最明显的潜在商业应用是制药研究， 尤其是药物研发 核磁共振广泛用于这一应用领域的目标 分析、代谢研究、组合化学和一般结构说明。 其他应用行业包括生物技术、化学产品研究和 发展，以及一般的分析化学研究（政府实验室， 大学等）

项目成果

Multiplexed NMR: an automated CapNMR dual-sample probe.

多重 NMR：自动化 CapNMR 双样品探针。

• DOI: 10.1021/ac101003f
• 发表时间: 2010
• 期刊: Analytical chemistry
• 影响因子: 7.4
• 作者: Norcross,JamesA;Milling,CraigT;Olson,DeanL;Xu,Duanxiang;Audrieth,Anthony;Albrecht,Robert;Ruan,Ke;Likos,John;Jones,Claude;Peck,TimothyL
• 通讯作者: Peck,TimothyL