Multi-microcoil Probes for Capillary Scale NMR Detection

描述(由申请人提供)：这项SBIR工作的总体目标是 商业化小规模高分辨率核磁共振的研制 光谱学探针通过研究多个 单个探头中的样品。核磁共振在医药领域的广泛应用 和生物科技行业，但仍然是为数不多的分析 没有应用并行数据采集来提高数据采集率的方法 可以同时评估的样本数。这背后的原因是 本质上与数据采集所涉及的硬件有关。近期 学术结果表明，这些限制中的一些可以通过 使用小型微线圈；许多设计问题仍有待解决 与窄孔磁铁兼容的系统，这些磁铁在 工业背景。这些问题在第一阶段的工作中得到了解决 可行性评估的目的。这是MRM的第一步 公司计划将多线圈探头商业化。 建议的商业应用： 最直接和最明显的潜在商业应用是药物研究， 尤其是药物发现。核磁共振在这一应用领域被广泛应用于靶向 分析、新陈代谢研究、组合化学和一般结构说明。 其他应用行业包括生物技术、化学产品研究和 开发和一般分析化学研究(政府实验室、 大学等)

DESCRIPTION (Provided by Applicant): The overall goal of this SBIR effort is to develop commercial small-scale high-resolution nuclear magnetic resonance (NMR) spectroscopy probes to increase throughput via the investigation of multiple samples in a single probe. NMR is utilized extensively by the pharmaceutical and biotecimology industries, but remains one of the very few analytical methods in which parallel data acquisition has not been applied to increase the number of samples that can be simultaneously evaluated. The reasons behind this are intrinsically related to the hardware involved in data acquisition. Recent academic results have shown that some of these limitations can be overcome by the use of small micro coils; Many design issues still remain to make such systems compatible with the narrow bore magnets that are predominant in industrial settings. These issues are addressed in this Phase I effort for purposes of feasibility assessment. This serves as the first step in MRM Corporation's plans to commercialize multi-coil probes. PROPOSED COMMERCIAL APPLICATION: The most immediate and obvious potential commercial application is pharmaceutical research, particularly drug discovery. NMR is used extensively in this application area for target analysis, metabolic studies, combinatorial chemistry, and for general structural elucidation. Other industries of application include biotechnology, chemical product research and development, and generally analytical chemical research (government laboratories, universities, etc.)