MICROCOIL-BASED NMR PROBES FOR CAPILLARY LC DETECTION

用于毛细管液相色谱检测的基于微线圈的 NMR 探头

• 批准号: 6529847
• 负责人: TIMOTHY L PECK
• 金额: $ 3.93万
• 依托单位: MAGNETIC RESONANCE MICROSENSORS CORP
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529847
• 关键词: dyes; liquid chromatography; nuclear magnetic resonance spectroscopy; reagent /indicator; technology /technique development

DESCRIPTION: (Applicant's description) The goal of this Phase II SBIR effort is to enable for the first time a complete capillary-based NMR detection solution for capillary LC (cLC). The primary benefit of capillary LC is enhanced separation efficiency. The primary benefit of microcoil NMR probe technology is enhanced mass sensitivity while simultaneously maintaining superior fluidics and chromatographic integrity. SBIR funding will enable the MRM team responsible for development of the first ever picomole sensitivity probe for high resolution NMR to develop a series of probes performance-optimized for cLC. This hyphenated technology combination has high potential for significantly impacting the fields of drug discovery, chemical products development, and other analytical-based industries. PROPOSED COMMERCIAL APPLICATION: Not Available

描述：（申请人的描述）本阶段II SBIR工作的目标是 首次实现了基于毛细管的完整NMR检测解决方案 毛细管LC（cLC）。毛细管LC的主要优势得到增强 分离效率微弹簧圈核磁共振探针技术的主要优点是 增强的质量灵敏度，同时保持上级射流 和色谱完整性。SBIR资金将使MRM团队 负责开发第一个皮摩尔灵敏度探针， 高分辨率NMR开发一系列性能优化的探针， cLC。这种技术组合具有很高的潜力， 对药物研发、化学产品 开发和其他基于分析的行业。 拟定商业应用： 不可用