MICROCOIL NMR: EXTENDING FIELD LIMITS OF HIGH RESOLUTION

描述(逐字摘自申请者摘要)：该项目的总体目标 研究的目的是扩展目前核磁共振波谱学的上限。 核磁共振微线圈的可伸缩性优势，从而使 使用最高场强的极窄口径磁铁的时间 目前可连接到最高质量的定制核磁共振探针 目前可以达到的灵敏度。这一独特而强大的组合 提高核磁共振灵敏度的磁铁和探头技术也提供了 固有的成本优势。这一进步对其他方面的潜在影响 高场、高分辨率核磁共振的指数性能与成本壁垒 将此类系统的费用大幅降低5-10倍。建议数 研究将作为后续工作的可行性论证 商业化，使高场核磁共振在 商业、学术和政府方面相对较快的时间框架 实验室。NIH的支持将使小学的研究评估 进行后续商业化所需的技术因素，并将 明确推动技术发展方向的第一步 被定义为具有国家意义的一种。 建议的商业应用：不可用

DESCRIPTION (Verbatim from Applicant's Abstract): The overall goal of this study is to extend the present upper field limits of NMR spectroscopy by using the scaling advantages of NMR microcoils, and therefore enable for the first time the use of very narrow bore magnets of the highest field strength currently attainable coupled to custom NMR probes of the highest mass sensitivity currently attainable. This unique and powerful combination of magnet and probe technology for increased NMR sensitivity also provides inherent cost advantages. The potential impact of this advance on the otherwise exponential performance vs. cost barrier of high field, high resolution NMR is to substantially lower expenses of such systems by factor of 5-10. The proposed research will serve as a demonstration of feasibility for subsequent commercialization that offers to bring high field NMR into common use in a relatively rapid time frame in commercial, academic, and government laboratories. NIH support will enable research assessment of the primary technology factors required to carry out subsequent commercialization, and will facilitate a first step in a direction for technology development explicitly defined as one of national significance. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE