MICROCOIL NMR: EXTENDING FIELD LIMITS OF HIGH RESOLUTION

描述（来自申请人摘要的逐字）：本申请的总体目标 研究的目的是扩大目前的上限领域的NMR光谱使用 NMR微线圈的缩放优势，因此能够实现第一个 时间的使用非常狭窄的孔磁铁的最高磁场强度 目前可达到的耦合到定制的核磁共振探针的最高质量 目前的敏感度。这种独特而强大的组合， 用于增加NMR灵敏度的磁体和探针技术还提供 固有的成本优势。这一进展对其他方面的潜在影响 高场、高分辨率NMR的指数性能与成本壁垒， 以将这种系统的费用显著降低5-10倍。拟议 研究将作为后续可行性的示范 商业化，提供了使高场核磁共振进入共同使用， 在商业、学术和政府方面， laboratories. NIH的支持将使研究评估的主要 进行后续商业化所需的技术因素，并将 为明确技术发展方向迈出第一步 被定义为具有国家意义的一个。 拟议商业应用：不可用

DESCRIPTION (Verbatim from Applicant's Abstract): The overall goal of this study is to extend the present upper field limits of NMR spectroscopy by using the scaling advantages of NMR microcoils, and therefore enable for the first time the use of very narrow bore magnets of the highest field strength currently attainable coupled to custom NMR probes of the highest mass sensitivity currently attainable. This unique and powerful combination of magnet and probe technology for increased NMR sensitivity also provides inherent cost advantages. The potential impact of this advance on the otherwise exponential performance vs. cost barrier of high field, high resolution NMR is to substantially lower expenses of such systems by factor of 5-10. The proposed research will serve as a demonstration of feasibility for subsequent commercialization that offers to bring high field NMR into common use in a relatively rapid time frame in commercial, academic, and government laboratories. NIH support will enable research assessment of the primary technology factors required to carry out subsequent commercialization, and will facilitate a first step in a direction for technology development explicitly defined as one of national significance. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE