MICROCOIL-BASED NMR PROBES FOR CAPILLARY LC DETECTION

描述：(申请者描述)此第二阶段SBIR工作的目标是 首次实现基于毛细管的完整核磁共振检测解决方案 用于毛细管层析(CLC)。增强了毛细管LC的主要优点 分离效率。微线圈核磁共振探头技术的主要好处是 增强质量敏感度，同时保持卓越的流体性能 和层析完整性。SBIR资金将使MRM团队能够 负责开发有史以来第一个皮摩尔灵敏度探头 高分辨率核磁共振将开发一系列性能优化的探针 《中图法》这种连字符技术组合具有很高的潜力 对药物发现、化学产品等领域产生重大影响 开发和其他以分析为基础的行业。 建议的商业应用： 不可用

DESCRIPTION: (Applicant's description) The goal of this Phase II SBIR effort is to enable for the first time a complete capillary-based NMR detection solution for capillary LC (cLC). The primary benefit of capillary LC is enhanced separation efficiency. The primary benefit of microcoil NMR probe technology is enhanced mass sensitivity while simultaneously maintaining superior fluidics and chromatographic integrity. SBIR funding will enable the MRM team responsible for development of the first ever picomole sensitivity probe for high resolution NMR to develop a series of probes performance-optimized for cLC. This hyphenated technology combination has high potential for significantly impacting the fields of drug discovery, chemical products development, and other analytical-based industries. PROPOSED COMMERCIAL APPLICATION: Not Available