Crystallographic Study of Chemokines /Chemokine Receptor

趋化因子/趋化因子受体的晶体学研究

• 批准号: 6753231
• 负责人: Jacek T Lubkowski
• 金额: --
• 依托单位: DIVISION OF CLINICAL SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6753231
• 关键词: X ray crystallography; antiinfective agents; asparaginase; biological signal transduction; chemokine; chemotaxis; computer data analysis; cytokine receptors; defensins; enzyme mechanism; enzyme structure; human immunodeficiency virus; liquid chromatography; protein protein interaction; protein structure; receptor coupling; virus infection mechanism

Our section is investigating the structural basis of intercellular signaling via chemotaxis and the role of chemokines in the process of viral infection, as well as correlating the structures of defensins with their antimicrobial and chemotactic properties. We are also studying the enzymatic mechanism and specificity of L-asparaginases. Although we primarily use X-ray crystallography in our studies, our research techniques also extend into biochemistry and molecular biology. Our recent efforts have been concentrated in three distinct areas: 1) chemokines and chemokine receptors, 2) beta-defensins, and 3) L-asparaginases.

我们的部分是调查通过趋化性和趋化因子在病毒感染的过程中的作用，以及相关的防御素的结构与其抗菌和趋化特性的细胞间信号的结构基础。我们也在研究L-天冬酰胺酶的酶促机制和特异性。虽然我们在研究中主要使用X射线晶体学，但我们的研究技术也延伸到生物化学和分子生物学。我们最近的努力集中在三个不同的领域：1）趋化因子和趋化因子受体，2）β-防御素，和3）L-天冬酰胺酶。