Crystallographic Studies of Chemokines, Chemokine Recept

趋化因子、趋化因子受体的晶体学研究

• 批准号: 7292110
• 负责人: Jacek T Lubkowski
• 金额: --
• 依托单位: DIVISION OF CLINICAL SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7292110
• 关键词: Crystallographic; Studies; Chemokines; Chemokine; Recept

Our section is investigating the structural basis of intercellular signaling via chemotaxis and the role of chemokines and defensins in the process of viral infection. We are also interested in correlating the structures of defensins and chemokines with their antimicrobial and chemotactic properties. We are also studying the enzymatic mechanism and specificity of human L-asparaginase and plant-type asparaginases, structures of urokinase plasminogen activator complex with its receptor as wel as TREM-Like Transcript protein 1 (TLT-1). Although we primarily use X-ray crystallography in our studies, our research techniques extend into biochemistry and molecular biology.

我们的部分是通过趋化性研究细胞间信号传导的结构基础，以及趋化因子和防御素在病毒感染过程中的作用。我们也有兴趣将防御素和趋化因子的结构与它们的抗菌和趋化特性相关联。我们还研究了人类L-天冬酰胺酶和植物型天冬酰胺酶的酶促机制和特异性，尿激酶纤溶酶原激活剂复合物与其受体的结构与TREM样转录蛋白1（TLT-1）一样。尽管我们在研究中主要使用X射线晶体学，但我们的研究技术扩展到生物化学和分子生物学。