Crystallographic Studies of Chemokines, Chemokine Recept

我们的部分是研究通过趋化性细胞间信号传导的结构基础，以及趋化因子和防御素在病毒感染过程中的作用。我们也有兴趣在相关的防御素和趋化因子的结构与它们的抗菌和趋化特性。我们还在研究人L-天冬酰胺酶和植物型天冬酰胺酶的酶促机制和特异性、尿激酶纤溶酶原激活物与其受体的复合物的结构以及TREM样转录蛋白1（TLT-1）。虽然我们在研究中主要使用X射线晶体学，但我们的研究技术延伸到生物化学和分子生物学。本研究主要集中在三个方面：1）趋化因子及其受体，2）α-防御素和β-防御素，3）尿激酶纤溶酶原激活物及其受体复合物，4）TLT-1

Our section is investigating the structural basis of intercellular signaling via chemotaxis and the role of chemokines and defensins in the process of viral infection. We are also interested in correlating the structures of defensins and chemokines with their antimicrobial and chemotactic properties. We are also studying the enzymatic mechanism and specificity of human L-asparaginase and plant-type asparaginases, structures of urokinase plasminogen activator complex with its receptor as wel as TREM-Like Transcript protein 1 (TLT-1). Although we primarily use X-ray crystallography in our studies, our research techniques extend into biochemistry and molecular biology. Our recent efforts have been concentrated inthree distinct areas: 1) chemokines and chemokine receptors, 2)alpha- and beta-defensins, 3) Complex of urokinase plasminogen activator and its receptor, 4) TLT-1