Crystallographic Studies of Chemokines, Chemokine Recept

趋化因子、趋化因子受体的晶体学研究

• 批准号: 7331715
• 负责人: Jacek T Lubkowski
• 金额: --
• 依托单位: DIVISION OF CLINICAL SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7331715
• 关键词: Crystallographic; Studies; Chemokines; Chemokine; Recept

One of the most significant accomplishments was to show a strong inhibitory properties of human defensin 5 (HD5) against the papillomaviruses. These properties make HD5 a potential candidate for the topical agent in preventing the papillomavirus infection.The other accomplishment was an identification of several structural determinants of chemotaxis in molecules of human beta-defensins. In broad structural and functional studies of mutants of human beta-defensin 1, we characterized (for the first time in case of defensins) a draft of the epitope involved in the binding and activation of the chemokine receptor CCR6.

最重要的成就之一是显示了人防御素5（HD 5）对乳头瘤病毒的强抑制特性。这些特性使HD 5成为预防乳头瘤病毒感染的局部药物的潜在候选者。另一项成就是鉴定了人β-防御素分子中趋化性的几个结构决定因素。在对人β-防御素1突变体的广泛结构和功能研究中，我们表征了（在防御素的情况下首次）参与趋化因子受体CCR 6结合和激活的表位草案。