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Crystallographic Studies of Chemokines, Chemokine Recept

Crystallographic Studies of Chemokines, Chemokine Recept
趋化因子、趋化因子受体的晶体学研究
批准号：
7331715
负责人：
Jacek T Lubkowski
金额：
$0.0万
依托单位：
DIVISION OF CLINICAL SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7331715
关键词：
CrystallographicStudiesChemokinesChemokineRecept

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英文摘要
One of the most significant accomplishments was to show a strong inhibitory properties of human defensin 5 (HD5) against the papillomaviruses. These properties make HD5 a potential candidate for the topical agent in preventing the papillomavirus infection.The other accomplishment was an identification of several structural determinants of chemotaxis in molecules of human beta-defensins. In broad structural and functional studies of mutants of human beta-defensin 1, we characterized (for the first time in case of defensins) a draft of the epitope involved in the binding and activation of the chemokine receptor CCR6.
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Studies of Proteins with Important Roles in Immunology andor Cancer Biology
  • 批准号：
    7592911
  • 项目类别：
  • 资助金额：
    $14.83万
  • 财政年份：
    --
  • 负责人：
    Jacek T Lubkowski
  • 依托单位：
    DIVISION OF BASIC SCIENCES - NCI
Crystallographic Studies of Chemokines, Chemokine Recept
Studies of Proteins with Important Roles in Immunology andor Cancer Biology
  • 批准号：
    7965618
  • 项目类别：
  • 资助金额：
    $66.11万
  • 财政年份：
    --
  • 负责人：
    Jacek T Lubkowski
  • 依托单位：
    DIVISION OF BASIC SCIENCES - NCI
Crystallographic studies of chemokine receptors and their ligands
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