Structural studies of teh TREM family of proteins

TREM 蛋白质家族的结构研究

• 批准号: 7338827
• 负责人: Jacek T Lubkowski
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7338827
• 关键词: Structural; studies; teh; TREM; family

The most significant accomplishment of recent year was the structure solution of the soluble fragment of human TLT-1. We also showed that the soluble variant of this protein exists in vivo, making our finding more relevant. In the process of our efforts while working with TLT-1, we developed the first protocol for expression and folding of the functional preparation of TLT-1 at the preparative scale.

最近一年最重要的成就是人类TLT-1的可溶性碎片的结构解决方案。我们还表明，该蛋白质的可溶性变体在体内存在，使我们的发现更加相关。在与TLT-1合作时的努力过程中，我们开发了第一个在制备量表上表达和折叠TLT-1的表达和折叠的方案。