CORE--CELL SCIENCES AND IMMUNOCHEMISTRY

描述(由申请人提供)： 这是一个继续细胞科学和免疫化学核心(CSIC)的请求.这一核心自1998年7月建立以来，一直很好地服务于2001年申请书中概述的四个项目。核心的功能仍然是为免疫化学、自身抗体分析和细胞因子测量提供及时、质量控制、成本效益高的服务的中心资源。此外，核心将提供建议，并将进行实验，以产生具有所需特异性的T-T和B-B杂交瘤。核心将开发新的和改进的程序，使调查人员能够随着项目研究需求的发展而提出新的和重要的问题。CSIC将在从肾脏和唾液腺克隆新的自身抗原方面提供专业知识和帮助。核心主任由联合主任和助理主任协助。已经招聘了四名具有不同专业知识的顾问。这些服务包括重组抗原和多肽、抗原制备、自身抗体检测、免疫组织学、流式细胞术和杂交瘤的产生。它是 预计中投公司将继续为本次竞争续签中概述的所有四个项目提供服务。

DESCRIPTION (provided by applicant): This a request to continue the Cell Sciences and Immunochemistry Core (CSIC). This Core has been established since July 1998 and has served the four projects well as outlined in the -01 application. The function of the Core remains to provide a central resource for timely, quality control, cost-effective services in immunochemistry, autoantibody assays, and cytokine measurements. In addition, the Core will provide advice and will carry out experiments to generate T-T and B-B hybridomas with desired specificities. The Core will develop new and improved procedures that will permit the investigators to ask novel and important questions as the research needs of the projects evolve. The CSIC will provide expertise and help in cloning new autoantigens from both kidney and salivary glands. The Director of the Core is assisted by the Co-Director and the Assistant Director. Four consultants with diverse expertise have been recruited. The services include recombinant antigens and peptides, antigen preparation, autoantibody assays, immunohistology, flow cytometry, and hybridoma generation. It is expected the CSIC will continue to serve all four projects as outlined in this competitive renewal.