Neuroimaging of language production using overt speech

使用公开言语进行语言产生的神经影像

• 批准号: 6626297
• 负责人: Randi C Martin
• 金额: $ 5.98万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6626297
• 关键词: adult human (21+); aphasia; behavior test; behavioral /social science research tag; bioimaging /biomedical imaging; biological signal transduction; brain imaging /visualization /scanning; brain mapping; clinical research; frontal lobe /cortex; functional magnetic resonance imaging; hemodynamics; human subject; language; method development; neural information processing; semantics; speech; stimulus /response

DESCRIPTION (provided by applicant): The proposed research will test methods for functional magnetic resonance imaging (fMRI) studies of language production using overt speech responses. Most fMRI studies of language production have used covert speech because of the susceptibility of this imaging method to movement artifacts. The use of covert speech, however, prevents the experimenter from monitoring subjects' compliance with the task and from obtaining important behavioral measures that could be related to the MR signal. The need to evaluate the accuracy of subjects' performance is particularly critical for subjects with language impairments. The proposed experiments will evaluate single word, phrase and sentence production using tasks in which subjects can produce the target responses within a short time period following stimulus onset. An event-related analysis will be used which allows for ignoring images collected during actual speech movements that occur prior to the hemodynamic response to cortical processing. Methods will be developed for recording subjects' responses and for amplifying the signal using adaptive noise cancellation techniques. Both normal and aphasic patients will be tested in a word production experiment and normal individuals will be tested in a phrase and sentence production experiment. If responses extend into the hemodynamic response for some conditions for either normal subjects or aphasic patients, additional analysis techniques will be employed in an attempt to co-vary out signal changes induced by movement. The proposed studies will also provide preliminary information on substantive issues concerning the role of the left inferior frontal cortex in language production. Previous lesion and neuroimaging studies suggest that the left frontal cortex is involved in using semantic information to select a response from competitors and in maintaining semantic information in short-term memory. The proposed studies will address whether the same brain region is involved in both. If these methods provide reliable and interpretable results, they will provide a means of determining the neural structures involved in producing speech for single-word and multi-word utterances. These methods could be used to address a number of health-related issues including evaluating reorganization of cortical function following recovery from stroke or other brain injury and determining language areas prior to surgery that might impinge on these areas.

描述(由申请人提供)：建议的研究将测试方法 语言产生的功能磁共振成像(FMRI)研究 使用公开的语音回应。大多数关于语言产生的功能磁共振研究都使用了 隐蔽的语言，因为这种成像方法对运动很敏感 手工艺品。然而，隐蔽语言的使用阻止了实验者 监控受试者对任务的遵从性，以及获得重要的 可能与磁共振信号有关的行为测量。评估的必要性 受试者表现的准确性对以下受试者尤为重要 语言障碍。拟议的实验将评估单个单词、短语 使用受试者可以产生目标的任务来产生句子 在刺激开始后的短时间内作出反应。与事件相关的 将使用允许忽略在实际操作期间收集的图像的分析 大脑皮质血流动力学反应之前发生的言语运动 正在处理。将开发记录受试者反应的方法和用于 使用自适应噪声抵消技术放大信号。都是正常的 并对失语症患者进行词汇产生实验和正常测试 每个人将在短语和句子产生实验中接受测试。如果 在某些情况下，反应延伸到血流动力学反应中 正常受试者或失语症患者，额外的分析技术将 用来尝试改变由运动引起的信号变化。这个 拟议的研究还将提供关于实质性问题的初步信息。 关于左下额叶皮质在语言产生中的作用。 先前的损伤和神经成像研究表明，左侧额叶皮质 参与使用语义信息来选择来自竞争对手的回应，以及 在短期记忆中保持语义信息。建议进行的研究 将解决这两个问题是否涉及相同的大脑区域。 如果这些方法提供可靠和可解释的结果，它们将提供 确定与产生语音有关的神经结构的方法 单字和多字发声。这些方法可以用来解决 一些与健康有关的问题，包括评估皮质的重组 中风或其他脑损伤恢复后的功能和确定 手术前可能会影响这些区域的语言区域。