HEALIH EFFECTS AND GEOCHEMISTRY OF ARSENIC AND LEAD

砷和铅的健康效应和地球化学

• 批准号: 6659830
• 负责人: Joseph H Graziano
• 金额: $ 219.93万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6659830
• 关键词: arsenic; environmental contamination; environmental toxicology; hazardous substances

This proposal is submitted in response to RFA ES-99-001, entitled with Superfund Hazardous Substances Basic Research Program. The contamination of soils and drinking water with As and Pb are associated with major public health, remedial, and environmental policy problems. As is found in soil or water at the majority of Superfund sites while Pb is a soil-borne contaminant of concern at approximately 300. This proposal seeks to obtain new knowledge, and train multi-disciplinary pre- and post-doctoral students, concerning the bioavailability of soil Pb in humans, and the bioavailability and/or geochemistry at four Superfund sites in the U.S., two contaminated with Pb and two with As. It also encompasses epidemiologic and geochemistry studies of As in drinking water in Bangladesh which focus on carcinogenic, reproductive and childhood effects of As exposure. We also devote resources to the development of practical remediation strategies for As in wastewater in drinking water. The proposal includes four biomedical research projects: 1) Bioavailability of Soil Pb and As in Humans; 2) Genotoxic Mechanisms of As in Mammalian Cells; 3) A Cohort Study of Aresnicosis in Bangladesh; 4) Environmental As, Pregnancy, and Children's Health. The biomedical research is directly related to that which occurs in three non- biomedical projects: 5) As Mobilization and Bangladesh Groundwater; 6) Redistribution of As at Sites in NF and Maine; and 7) Assessment and Remediation for as Enrichments in Groundwater. The research projects are supported by three Research Support Core Labs: 8) Trace Metals; 9) Geochemistry; and 10) Hydrology An Administrative Core includes an Information Dissemination Program and a Government Liaison & Outreach Program. Finally, a Training Core coordinates multi- disciplinary education and interaction among pre- and post-doctoral trainees support by this proposal as well as other training grant.

本提案是根据RFA ES-99-001提交的，标题为“超级基金有害物质基础研究计划”。砷和铅对土壤和饮用水的污染与重大的公共卫生、补救和环境政策问题有关。在大多数超级基金场址的土壤和水中都发现了铅，而铅是一种土壤传播的污染物，其含量约为300。本提案旨在获取新的知识，并培养多学科的博士生和博士后，研究人类土壤铅的生物有效性，以及美国四个超级基金站点的生物有效性和/或地球化学，其中两个受铅污染，两个受砷污染。它还包括对孟加拉国饮用水中砷的流行病学和地球化学研究，重点是接触砷的致癌、生殖和儿童影响。我们还投入资源开发饮用水废水中砷的实用修复策略。提案包括四个生物医学研究项目：1)土壤铅和砷在人体中的生物有效性；2)砷对哺乳动物细胞的遗传毒性机制；3)孟加拉地区尘肺队列研究；4)环境、怀孕和儿童健康。生物医学研究与三个非生物医学项目的研究直接相关：5)As动员和孟加拉国地下水；6)在北海道和缅因州的场地重新分配砷；7)地下水砷富集的评价与修复。研究项目由三个研究支持核心实验室支持：8)微量金属；9)地球化学;行政核心包括信息发布计划和政府联络与外联计划。最后，一个培训核心协调多学科的教育，以及在本建议和其他培训补助金支持下的博士后和博士后学员之间的互动。