Health Effects and Geochemistry of Arsenic and Manganese

本提案是为响应RFA-ES-10-010“超级基金有害物质研究和培训计划（P42）”而提交的。拟议的工作包括在新泽西州维尼兰市最严重的砷（As）超级基金遗址进行大量工作。它还涉及居住在孟加拉国的砷和锰（Mn）暴露的成人和青少年的独特流行病学研究，以及砷诱导的表观遗传失调的重要机制调查。与过去一样，哥伦比亚大学SRP中心包括生物医学和非生物医学研究之间的平衡。

This proposal is submitted in response to RFA-ES-10-010, entitled "Superfund Hazardous Substance Research and Training Program (P42)." The proposed work involves substantial work at the single most serious arsenic (As) Superfund site in Vineland, NJ. It also involves unique epidemiologic studies of As and Manganese (Mn)-exposed adults and adolescents residing in Bangladesh as well as an important mechanistic investigation of As-induced epigenetic dysregulation. As in the past, the Columbia University SRP Center includes a balance between biomedical and non-biomedical research. The proposal includes three biomedical research projects:1) Health Effects of As Longitudinal Study (HEALS); 2) Consequences of As and Mn Exposure on Children's Health; and 3) Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation. The biomedical research is intimately intertwined with three nonbiomedical projects: 4) Arsenic, Iron, Sulfur and Organic Carbon Speciation, and Their Impact on Groundwater Arsenic; 5) Application of Enhanced Mitigation Methods for Groundwater As at US Superfund Sites; and 6) Defining the Sustainable Uses of Low-As Aquifers in Bangladesh. The Projects are supported by four Research Support Core Laboratories: 8) Data Management; 9) Trace Metals; 10) Biogeochemistry; and 11) Hydrogeology. A Research Translation Core (RTC) entitled, "Collaborating with government and the NIEHS SRP Center: As and Mn Exposure in Groundwater" works with several government agencies to help understand and solve their local groundwater problems. Finally, the RTC will work closely with the Community Engagement Core (CEC) entitled "Promoting As Testing and Treatment to Reduce Health Risks for Residents in Maine." The CEC has developed naturally from our past biomedical and geochemical As research in Maine.