Health Effects and Geochemistry of Arsenic and Manganese

砷和锰的健康影响和地球化学

基本信息

批准号：
8717881
负责人：
Joseph H Graziano
金额：
$ 5.74万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-20 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8717881
关键词：
3-Dimensional Adolescent Adult Age Arsenic Asia Automobile Driving Bangladesh Biological Markers Biomedical Research Brain Carbon Cardiovascular Diseases Child Child health care Chronic Chronic Disease Cohort Studies Communication Communities Conceptions County Coupled DNA Methylation Data Disease Disease Outcome Dose Environmental Policy Epidemiologic Studies Epigenetic Process Equilibrium Goals Government Government Agencies Grant Hazardous Substances Health Histones Household In Situ Incidence Individual Injection of therapeutic agent Integration Host Factors Intelligence Intervention Investigation Iron Irrigation Knowledge Laboratories Literature Longitudinal Studies Lung Lung diseases Maine Manganese Maps Methods National Institute of Environmental Health Sciences New Jersey Oxalic Acids Participant Precipitation Process Public Health Pump Research Research Project Grants Research Support Research Training Risk Scientist Services Signal Recognition Particle Site Soil Source Structure Sulfur Superfund Techniques Testing Trace metal Training Programs Translating Translational Research Universities Water Water Supply Woman Work base cohort data management dosimetry drinking water executive function field study follow-up improved interest iron oxide land use magnetite ferrosoferric oxide microbial mortality neuropsychological novel strategies nutrition operation programs prospective pulmonary function remediation response scale up superfund site

项目摘要

This proposal is submitted in response to RFA-ES-10-010, entitled "Superfund Hazardous Substance Research and Training Program (P42)." The proposed work involves substantial work at the single most serious arsenic (As) Superfund site in Vineland, NJ. It also involves unique epidemiologic studies of As and Manganese (Mn)-exposed adults and adolescents residing in Bangladesh as well as an important mechanistic investigation of As-induced epigenetic dysregulation. As in the past, the Columbia University SRP Center includes a balance between biomedical and non-biomedical research. The proposal includes three biomedical research projects:1) Health Effects of As Longitudinal Study (HEALS); 2) Consequences of As and Mn Exposure on Children's Health; and 3) Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation. The biomedical research is intimately intertwined with three nonbiomedical projects: 4) Arsenic, Iron, Sulfur and Organic Carbon Speciation, and Their Impact on Groundwater Arsenic; 5) Application of Enhanced Mitigation Methods for Groundwater As at US Superfund Sites; and 6) Defining the Sustainable Uses of Low-As Aquifers in Bangladesh. The Projects are supported by four Research Support Core Laboratories: 8) Data Management; 9) Trace Metals; 10) Biogeochemistry; and 11) Hydrogeology. A Research Translation Core (RTC) entitled, "Collaborating with government and the NIEHS SRP Center: As and Mn Exposure in Groundwater" works with several government agencies to help understand and solve their local groundwater problems. Finally, the RTC will work closely with the Community Engagement Core (CEC) entitled "Promoting As Testing and Treatment to Reduce Health Risks for Residents in Maine." The CEC has developed naturally from our past biomedical and geochemical As research in Maine.

该提案是针对RFA-ES-10-010的响应，标题为“超级基金有害物质研究与培训计划（P42）”。拟议的工作涉及新泽西州Vineland的最严重的砷（AS）超级基金地点的大量工作。它还涉及居住在孟加拉国的AS和锰（MN）暴露成人和青少年的独特流行病学研究，以及对AS诱导的表观遗传失调的重要机械研究。与过去一样，哥伦比亚大学SRP中心包括生物医学和非生物医学研究之间的平衡。该提案包括三个生物医学研究项目：1）AS纵向研究的健康影响（HEALS）； 2）AS和MN暴露对儿童健康的后果； 3）营养对砷诱导的表观遗传失调的影响。生物医学研究与三个非生物医学项目密切相互交织：4）砷，铁，硫和有机碳的形成，及其对地下水砷的影响； 5）在美国超级基金地点应用地下水的缓解方法； 6）定义孟加拉国低水位含水层的可持续用途。这些项目得到了四个研究支持核心实验室的支持：8）数据管理； 9）痕量金属； 10）生物地球化学； 11）水文地质学。研究翻译核心（RTC）题为“与政府和NIEHS SRP中心合作：地下水中的AS和MN暴露”与几家政府机构合作，以帮助理解和解决他们当地的地下水问题。最后，RTC将与社区参与核心（CEC）紧密合作，名为“促进作为测试和治疗，以降低缅因州居民的健康风险”。 CEC从过去的生物医学和地球化学作为缅因州的研究中自然发展。