Health Effects and Geochemistry of Arsenic and Manganese

本提案是根据RFA-ES-10-010（标题为“超级基金危险物质研究和培训计划（P42）”）提交的。“拟议的工作涉及在新泽西州葡萄园最严重的砷（As）超级基金现场的大量工作。它还涉及独特的流行病学研究的As和锰（Mn）暴露的成年人和青少年居住在孟加拉国，以及作为诱导的表观遗传失调的重要机制调查。与过去一样，哥伦比亚大学SRP中心包括生物医学和非生物医学研究之间的平衡。 该提案包括三个生物医学研究项目：1）砷纵向研究（HEALS）的健康影响; 2）砷和锰暴露对儿童健康的后果; 3）营养对砷诱导的表观遗传失调的影响。生物医学研究与三个非生物医学项目密切相关：4）砷，铁，硫和有机碳形态，及其对地下水砷的影响; 5）在美国超级基金场地应用增强的地下水缓解方法;和6）定义孟加拉国低砷含水层的可持续利用。这些项目得到四个研究支持核心实验室的支持：8）数据管理; 9）痕量金属; 10）生物地球化学;和11）水文地质学。 一个名为“与政府和NIEHS SRP中心合作：地下水中的砷和锰暴露”的研究翻译核心（RTC）与几个政府机构合作，帮助了解和解决当地的地下水问题。最后，RTC将与社区参与核心（CEC）密切合作，题为“促进检测和治疗，以减少缅因州居民的健康风险。“CEC是从我们过去在缅因州进行的生物医学和地球化学As研究中自然发展起来的。

This proposal is submitted in response to RFA-ES-10-010, entitled "Superfund Hazardous Substance Research and Training Program (P42)." The proposed work involves substantial work at the single most serious arsenic (As) Superfund site in Vineland, NJ. It also involves unique epidemiologic studies of As and Manganese (Mn)-exposed adults and adolescents residing in Bangladesh as well as an important mechanistic investigation of As-induced epigenetic dysregulation. As in the past, the Columbia University SRP Center includes a balance between biomedical and non-biomedical research. The proposal includes three biomedical research projects:1) Health Effects of As Longitudinal Study (HEALS); 2) Consequences of As and Mn Exposure on Children's Health; and 3) Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation. The biomedical research is intimately intertwined with three nonbiomedical projects: 4) Arsenic, Iron, Sulfur and Organic Carbon Speciation, and Their Impact on Groundwater Arsenic; 5) Application of Enhanced Mitigation Methods for Groundwater As at US Superfund Sites; and 6) Defining the Sustainable Uses of Low-As Aquifers in Bangladesh. The Projects are supported by four Research Support Core Laboratories: 8) Data Management; 9) Trace Metals; 10) Biogeochemistry; and 11) Hydrogeology. A Research Translation Core (RTC) entitled, "Collaborating with government and the NIEHS SRP Center: As and Mn Exposure in Groundwater" works with several government agencies to help understand and solve their local groundwater problems. Finally, the RTC will work closely with the Community Engagement Core (CEC) entitled "Promoting As Testing and Treatment to Reduce Health Risks for Residents in Maine." The CEC has developed naturally from our past biomedical and geochemical As research in Maine.