Health Effects and Geochemistry of Arsenic and Manganese

本提案是根据RFA-ES-10-010号文件提交的，标题为“超级基金危险物质研究和培训计划(42页)”。拟议的工作涉及在新泽西州维尼兰德的单一最严重的砷(AS)超级基金地点进行大量工作。它还涉及居住在孟加拉国的暴露于砷和锰(Mn)的成年人和青少年的独特流行病学研究，以及对砷诱导的表观遗传失调的重要机制调查。与过去一样，哥伦比亚大学SRP中心包括生物医学和非生物医学研究之间的平衡。 该建议包括三个生物医学研究项目：1)砷纵向研究(HeALS)的健康效应；2)砷和锰暴露对儿童健康的影响；3)营养对砷诱导的表观遗传调控障碍的影响。生物医学研究与三个非生物医学项目密切相关：4)砷、铁、硫和有机碳的形态及其对地下水砷的影响；5)美国超级基金网站对地下水强化缓解方法的应用；6)孟加拉国低砷含水层的可持续利用。这些项目得到了四个研究支持核心实验室的支持：8)数据管理；9)痕量金属；10)生物地质化学；11)水文地质学。 题为“与政府和NIEHS SRP中心合作：地下水中砷和锰暴露”的研究翻译核心(RTC)与多个政府机构合作，帮助了解和解决当地的地下水问题。最后，RTC将与名为“促进检测和治疗以降低缅因州居民健康风险”的社区参与核心(CEC)密切合作。CEC是在我们过去在缅因州进行生物医学和地球化学研究的基础上自然发展起来的。

This proposal is submitted in response to RFA-ES-10-010, entitled "Superfund Hazardous Substance Research and Training Program (P42)." The proposed work involves substantial work at the single most serious arsenic (As) Superfund site in Vineland, NJ. It also involves unique epidemiologic studies of As and Manganese (Mn)-exposed adults and adolescents residing in Bangladesh as well as an important mechanistic investigation of As-induced epigenetic dysregulation. As in the past, the Columbia University SRP Center includes a balance between biomedical and non-biomedical research. The proposal includes three biomedical research projects:1) Health Effects of As Longitudinal Study (HEALS); 2) Consequences of As and Mn Exposure on Children's Health; and 3) Impact of Nutrition on Arsenic-Induced Epigenetic Dysregulation. The biomedical research is intimately intertwined with three nonbiomedical projects: 4) Arsenic, Iron, Sulfur and Organic Carbon Speciation, and Their Impact on Groundwater Arsenic; 5) Application of Enhanced Mitigation Methods for Groundwater As at US Superfund Sites; and 6) Defining the Sustainable Uses of Low-As Aquifers in Bangladesh. The Projects are supported by four Research Support Core Laboratories: 8) Data Management; 9) Trace Metals; 10) Biogeochemistry; and 11) Hydrogeology. A Research Translation Core (RTC) entitled, "Collaborating with government and the NIEHS SRP Center: As and Mn Exposure in Groundwater" works with several government agencies to help understand and solve their local groundwater problems. Finally, the RTC will work closely with the Community Engagement Core (CEC) entitled "Promoting As Testing and Treatment to Reduce Health Risks for Residents in Maine." The CEC has developed naturally from our past biomedical and geochemical As research in Maine.