Trace Metals Core

暴露于金属和类金属的生物标志物已被证明是流行病学研究的有力工具 旨在研究暴露与人类健康影响之间的联系。痕量金属核心实验室 成立于1994年，是我们NIEHS中心的一部分，并在NIEHS获得杰出评级 中心在1997年和2002年进行的现场访问。 实验室参与了多个质量控制计划，并有出色的过去记录 性能。生物医学研究项目#2、#3和#4，分别在孟加拉国和新西兰进行 汉普郡，提议测试一组关于接触辐射的机制和影响的新假说 饮用水中的砷和锰。这些项目总共需要分析60,000多个 生物标本；这一估计大约是成功获得的70,000个标本的总数 在过去的五年中进行了衡量。 将被分析和储存在痕量金属核心实验室的生物样本包括血液、尿液和 脚趾甲。采用的方法包括石墨炉原子吸收分光光度测定法。 石墨炉原子吸收光谱分析(GFAAS)(如尿中砷和血中铅)，电感耦合等离子体质谱 动态反应池(ICPMS-DRC)(例如，血液中的总砷、锰和硒)，高效液相色谱与电感耦合等离子体质谱联用 例如尿液和血液中的砷代谢物)和酶联免疫吸附试验技术(Clara细胞蛋白-16)。踪迹 金属核心实验室设备齐全，可以免费执行这些分析和其他要求的分析 这项超级基金基础研究计划的成员。

Biomarkers of exposure to metals and metalloids have proven to be powerful tools for epidemiologic studies that seek to study associations between exposures and human health effects. The Trace Metals Core Lab came into existence in 1994 as part of our NIEHS Center, and received a rating of outstanding at NIEHS Center site visits that occurred in 1997 and 2002. The Laboratory participates in multiple quality control programs and has an outstanding record of past performance. Biomedical research Projects #2, #3 and #4, which take place in Bangladesh and New Hampshire, propose to test a set of novel hypotheses concerning the mechanisms and effects of exposure to As and Mn from drinking water. These projects collectively require the analysis of more than 60,000 biological specimens; this estimate approximates the total of 70,000 specimens that have been successfully measured during the past five years. The biological specimens to be analyzed and stored in the Trace Metals Core Lab include blood, urine and toenails. The methodologies employed will include graphite furnace atomic absorption spectrophotometry (GFAAS) (e.g., arsenic in urine and lead in blood), inductively-coupled plasma mass spectrometry with dynamic reaction cell (ICP-MS-DRC) (e.g., total As, Mn and Se in blood), HPLC coupled to ICP-MS-DRC (e.g., arsenic metabolites in urine and blood), and ELISA technology (clara cell protein-16). The Trace Metals Core Laboratory is well equipped to carry out these and other requested analyses at no cost to members of this Superfund Basic Research Program.