9.4T/ 65cm BORE MR SYSTEM

9.4T/65cm孔径磁共振系统

• 批准号: 6501224
• 负责人: KAMIL UGURBIL
• 金额: $ 150万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6501224
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; brain imaging /visualization /scanning; functional magnetic resonance imaging; magnetic resonance imaging; neurochemistry

DESCRIPTION (provided by applicant): The aim of this application is to locate a state-of-the-art 9.4T/65cm bore MRI system at the University of Minnesota's Center for Magnetic Resonance Research (CMRR) for non-human primate and human MR imaging and spectroscopy studies of brain function and neurochemistry. This system will be the first of its kind, providing for the first time, a 9.4T field magnitude with a sufficiently large bore size to conduct human and non-human primate studies. No other system at this field strength with such a bore size exists. This system will become a shared resource for CMRR collaborators at the Wisconsin Regional Primate Research Center (WRPR) in Madison, Wisconsin, and will serve the needs of numerous investigators from several institutions located in the Midwest and the East coast. With its in-house staff of fifty five investigators and support staff, the expertise in high field magnetic resonance research, and support as a Biotechnology Research Resource (BTRR) by NIH for "High Field Magnetic Resonance Imaging and Spectroscopy", the CMRR is an ideal facility to support the shared instrument and its users. The proposed 9.4T system will have a Varian Associates, Inc. lnova console and a Magnex Scientific, Inc. superconducting magnet with 7 G/cm shielded gradients and high-order shims. The magnet will have a 65 cm inside diameter that will step to a gradient/shim coil inside diameter of 40cm. The gradient set will serve as a "head" gradient for human studies, while providing large access for non-human primate work including awake monkeys. With four receiver channels and two transmitter channels, this system will be capable of multi-nuclear spectroscopy from 12 MHz to 400 MHz with full second-channel decoupling capability. The echo-planar imaging (EPI) compatible gradients will make it possible to perform dynamic fMRl studies. Signal-to-noise and spectroscopic resolution at 9.4T has been demonstrated to be twice that of standard 4.7T animal research systems for 1H nuclei and 4 times for the lower gyromagnetic ratio 170 nucleus. Overall, this non-human primate and human primate dedicated NMR system will provide state-of-the-art performance and capability for imaging of laboratory animals and humans for the first time at such high magnetic fields.

描述（由申请人提供）：本申请的目的是在明尼苏达大学磁共振研究中心（CMRR）定位最先进的9.4T/65cm孔系统MRI系统，用于非人类灵长类动物和人类MR MR成像和脑功能和神经化学的光谱研究。 该系统将是第一次提供的第一个系统，它是9.4 t场的幅度，其孔径足够大，可以进行人类和非人类的灵长类动物研究。 在这种野外强度上，没有其他系统的其他系统存在。 该系统将成为威斯康星州麦迪逊市威斯康星州地区灵长类动物研究中心（WRPR）的CMRR合作者共享资源，并将满足来自中西部和东海岸几个机构的众多调查人员的需求。 NIH凭借其五十名五名研究人员和支持人员的内部工作人员，高场磁共振研究的专业知识，以及作为生物技术研究资源（BTRR）的支持，用于“高场磁共振成像和光谱”，CMRR是支持共享工具及其用户的理想设施。 拟议的9.4T系统将具有Varian Associates，Inc。Lnova控制台和Magnex Scientific，Inc。使用7 g/cm屏蔽的梯度和高阶垫片的超导磁铁。 磁铁的内径为65厘米，将梯度/垫片内径40厘米的梯度/垫片线圈。该梯度集将作为人类研究的“头”梯度，同时为包括清醒猴子在内的非人类灵长类动物作品提供大量访问。 使用四个接收器通道和两个发射机通道，该系统将能够具有从12 MHz到400 MHz的多核光谱，具有完整的第二通道解耦能力。 回声平面成像（EPI）兼容梯度将使进行动态FMRL研究成为可能。 在9.4T处的信号到噪声和光谱分辨率已证明是1H核的标准4.7 t动物研究系统的两倍，而较低的陀螺仪比率为170核的4倍。 总体而言，这种非人类灵长类动物和人类灵长类动物专用的NMR系统将在如此高的磁场上首次为实验动物和人类成像的最先进的性能和能力。