Institutional Center Cores for Advanced Neuroimaging

高级神经影像机构中心核心

• 批准号: 8699282
• 负责人: KAMIL UGURBIL
• 金额: $ 47.34万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8699282
• 关键词: Animal Model; Animals; Area; Basic Science; Biotechnology; Brain; Brain imaging; Center Core Grants; Clinic; Clinical Research; Complex; Computers and Advanced Instrumentation; Contrast Media; Core Facility; Development; Diffusion; Disease; Effectiveness; Electrophysiology (science); Engineering; Environment; Faculty; Foundations; Functional Magnetic Resonance Imaging; Funding; Grant; Health; Histology; Human; Human Resources; Image; Imagery; Individual; Institutes; Interdisciplinary Study; Investments; Laboratories; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Methodology; Minnesota; Mission; National Institute of Neurological Disorders and Stroke; Nervous system structure; Neurosciences; Neurosciences Research; Operative Surgical Procedures; Perfusion; Physics; Physiologic pulse; Positron-Emission Tomography; RF coil; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Science; Services; Spectrum Analysis; Techniques; Technology; Translational Research; United States National Institutes of Health; Universities; Wages; base; bioimaging; computerized data processing; image processing; imaging modality; instrumentation; molecular imaging; multidisciplinary; multimodality; nervous system disorder; neurochemistry; neuroimaging; new technology; ranpirnase; signal processing; single photon emission computed tomography; spectroscopic imaging; tool

DESCRIPTION (provided by applicant): The general aim of this proposal is to establish NINDS Institutional Center Core facilities that will augment the unique resources that exist at the Center for Magnetic Resonance Research (CMRR), University of Minnesota, for biomedical imaging, so as to maximize their utilization and impact on a large number of NINDS funded research projects on normal brain function and neurological disorders. This aim is based on the premise that developments in the last two decades have generated a plethora of magnetic resonance (MR) techniques, such as functional brain imaging (fMRI), neurochemical spectroscopy, perfusion imaging, diffusion imaging etc., that provide indispensable and otherwise unavailable measurement capabilities for studies of the brain in humans and in animal models of human diseased states. However, optimal use of these techniques requires advanced instrumentation, unique expertise, and complex auxiliary capabilities that include complementary measurements employing classical techniques (e.g. electrophysiology, and histology) and other imaging modalities such as PET. Access to these instrumentation and methodologies, especially at the cutting-edge, is virtually impossible in individual labs and requires interdisciplinary interactions in the area of spin-physics, RF engineering, signal and image processing, and brain sciences. The aim of this grant is to provide this access within the cooperative, multidisciplinary, and interactive research environment of CMRR, so as to enrich the effectiveness of and promote new research directions in a large number of ongoing NINDS funded research projects.

描述（由申请人提供）：本提案的总体目标是建立NINDS机构中心核心设施，以增强明尼苏达大学磁共振研究中心（CMRR）现有的生物医学成像独特资源，从而最大限度地利用和影响NINDS资助的大量关于正常脑功能和神经系统疾病的研究项目。这一目标的前提是，过去二十年的发展已经产生了大量的磁共振（MR）技术，如功能性脑成像（fMRI）、神经化学光谱学、灌注成像、扩散成像等，这些技术为人类大脑研究和人类疾病状态的动物模型提供了不可或缺的和不可用的测量能力。然而，这些技术的最佳使用需要先进的仪器、独特的专业知识和复杂的辅助能力，包括采用经典技术（如电生理学和组织学）和其他成像方式（如PET）的补充测量。获得这些仪器和方法，特别是在前沿，在单个实验室几乎是不可能的，并且需要在自旋物理学，射频工程，信号和图像处理以及脑科学领域的跨学科互动。这项资助的目的是在CMRR的合作、多学科和互动研究环境中提供这种访问，从而丰富大量正在进行的NINDS资助的研究项目的有效性并促进新的研究方向。