Institutional Center Cores for Advanced Neuroimaging

高级神经影像机构中心核心

• 批准号: 10005492
• 负责人: KAMIL UGURBIL
• 金额: $ 43.35万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10005492
• 关键词: Animal Model; Animals; Basic Science; Brain; Clinical Research; Complex; Computers and Advanced Instrumentation; Core Facility; Data Analyses; Disease; Effectiveness; Electrophysiology (science); Engineering; Environment; Functional Magnetic Resonance Imaging; Funding; Grant; Health; Histology; Human; Image; Individual; Magnetic Resonance; Magnetic Resonance Imaging; Measurement; Methodology; Minnesota; Mission; National Institute of Neurological Disorders and Stroke; Neurosciences; Neurosciences Research; Operative Surgical Procedures; Physiologic pulse; RF coil; Research; Research Personnel; Research Project Grants; Research Support; Resources; Science; Spectrum Analysis; Techniques; Technology; Translational Research; Universities; Visualization; bioimaging; computerized data processing; data visualization; human model; image processing; instrumentation; large scale data; magnetic field; multidisciplinary; multimodality; nervous system disorder; neuroimaging; new technology; ranpirnase; spectroscopic imaging; tool; virtual

The general aim of this proposal is to continue the successful NINDS Institutional Center Cores (P30 NS076408) at the Center for Magnetic Resonance Research (CMRR), University of Minnesota (UMN). These Cores offer state-of-the-art instrumentation, advanced technology, and unique expertise for biomedical imaging in CMRR so as to provide cutting edge resources and facilities to investigators who have existing NINDS-funded research projects serving the NINDS mission through “basic, translational, and clinical research on the normal and diseased nervous system”. In the last two and a half decades, magnetic resonance (MR) techniques have evolved to become indispensable in studies of the brain in health and disease by providing otherwise unavailable measurement capabilities in humans and animal models. The optimal use of these techniques requires advanced instrumentation, unique expertise, and complex auxiliary capabilities such as animal surgery, large-scale data and image processing, and complementary measurements employing classical techniques (e.g., electrophysiology and histology). Access to these facilities and methodologies, especially at the cutting-edge, is virtually impossible in individual labs. The proposed NINDS Center Cores will provide and encourage access to these advanced technologies and associated unique expertise to amplify NINDS funded neuroscience research. These aims will be accomplished through three scientific Cores: 1. MR Image Acquisition and Engineering Core (to provide application specific pulse sequences, and hardware, such as RF coils) (PI: Pierre-Francois van de Moortele; co-PI Gulin Oz) 2. MR Data Analysis and Visualization Core (to provide applications specific image and spectroscopic analysis tools and support) (PI: Christophe Lenglet; co-PI Noam Harel) 3. Multimodality Core (to support complementary non-imaging measurement capabilities) (PI: Geoff Ghose) The overall aim of this grant is to provide this access within the multidisciplinary, and interactive research environment of CMRR, so as to enrich the effectiveness of and promote new research directions in a large number of ongoing NINDS funded research projects.

本提案的总体目标是继续成功的NINDS机构中心核心（P30 NS 076408），明尼苏达大学磁共振研究中心（CMRR） （UMN）。这些核心提供最先进的仪器、先进的技术和独特的 在CMRR生物医学成像的专业知识，以提供尖端的资源和设施， 现有的NINDS资助的研究项目为NINDS使命服务的研究人员， “关于正常和患病神经系统的基础、转化和临床研究”。在过去 25年来，磁共振（MR）技术已经发展成为 在健康和疾病的大脑研究中不可或缺的， 在人类和动物模型中的测量能力。这些技术的最佳使用 需要先进的仪器、独特的专业知识和复杂的辅助能力，如 动物手术、大规模数据和图像处理以及补充测量 采用经典技术（例如，电生理学和组织学）。使用这些设施， 方法，特别是在尖端，在个别实验室几乎是不可能的。拟议 NINDS中心核心将提供并鼓励获得这些先进技术， 相关的独特专业知识，以扩大NINDS资助的神经科学研究。这些目标将是 通过三个科学核心来实现： 1. MR图像采集和工程核心（提供应用特定脉冲序列， 和硬件，如RF线圈）（PI：Pierre-Francois货车de Moortele;共同PI Gulin Oz） 2. MR数据分析和可视化核心（提供应用程序特定的图像和 光谱分析工具和支持）（PI：Christophe Lenglet;共同PI Noam Harel） 3.多模态核心（支持互补的非成像测量功能）（PI： Geoff Ghose） 这项赠款的总体目标是在多学科和互动的范围内提供这种机会。 CMRR的研究环境，以丰富研究的有效性，促进新的研究 在大量正在进行的NINDS资助的研究项目的方向。

项目成果

Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: Preliminary evidence in adolescents with treatment-resistant depression.

• DOI: 10.1177/0269881120928203
• 发表时间: 2021-03
• 期刊: Journal of psychopharmacology (Oxford, England)
• 作者: Roy AV;Thai M;Klimes-Dougan B;Westlund Schreiner M;Mueller BA;Albott CS;Lim KO;Fiecas M;Tye SJ;Cullen KR
• 通讯作者: Cullen KR

Results and interpretation of a fitting challenge for MR spectroscopy set up by the MRS study group of ISMRM.

• DOI: 10.1002/mrm.28942
• 发表时间: 2022-01
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Marjańska M;Deelchand DK;Kreis R;2016 ISMRM MRS Study Group Fitting Challenge Team
• 通讯作者: 2016 ISMRM MRS Study Group Fitting Challenge Team

Adaptive virtual referencing for the extraction of extracellularly recorded action potentials in noisy environments.

• DOI: 10.1088/1741-2552/abb73c
• 发表时间: 2020-10-10
• 期刊: Journal of neural engineering
• 影响因子: 4
• 作者: Cruttenden CE;Zhu W;Zhang Y;Soon SH;Zhu XH;Chen W;Rajamani R
• 通讯作者: Rajamani R

A temporal decomposition method for identifying venous effects in task-based fMRI.

• DOI: 10.1038/s41592-020-0941-6
• 发表时间: 2020-10
• 期刊: Nature methods
• 影响因子: 48
• 作者: Kay K;Jamison KW;Zhang RY;Uğurbil K
• 通讯作者: Uğurbil K

Regional sex differences in neurochemical profiles of healthy mice measured by magnetic resonance spectroscopy at 9.4 tesla.

• DOI: 10.3389/fnins.2023.1278828
• 发表时间: 2023
• 期刊: FRONTIERS IN NEUROSCIENCE
• 影响因子: 4.3
• 作者: Tkac, Ivan;Xie, Tiankai;Shah, Nitya;Larson, Sarah;Dubinsky, Janet M.;Gomez-Pastor, Rocio;McLoughlin, Hayley S.;Orr, Harry T.;Eberly, Lynn E.;Oz, Gulin
• 通讯作者: Oz, Gulin