ADVANCED HIGH-RESOLUTION TWO-DIMENSIONAL X-RAY DETECTOR

先进的高分辨率二维 X 射线探测器

• 批准号: 6804688
• 负责人: JACQUELINE A JOHNSON
• 金额: $ 22.29万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6804688
• 关键词: X ray; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; electromagnetic radiation; imaging /visualization /scanning; radiation detector; radiodiagnosis

DESCRIPTION (provided by applicant): In recent years preventative medicine has proved invaluable to health. In addition, there have been numerous developments in machines and techniques but the "x-ray" is still a staple in medical diagnosis and disease prevention. The proposed new capability will improve the spatial resolution for x-ray detection and allow advances in the diagnosis and treatment of numerous diseases. Improved resolution and ease of read-out can only help in the speed and detail with which a problem can be diagnosed. In combination with complementary imaging methods, the proposed innovation has the potential to increase sensitivity to specific types of tissue damage. A main goal of the research is to develop improved spatial imaging using equal or reduced x-ray fluxes, in this way, the applicability of the technique can be increased. Using, what is in effect a solid-state x-ray detector means that transferring images to computer for analysis or storage is readily accomplished, enabling complementary techniques to be integrated. Current x-ray photon storage materials such as image plates are fundamentally limited in their spatial resolution by scattering in the read-out stage from grain boundaries in the polycrystalline materials, which are used. Imaging with a thin and transparent glass sheet as proposed here minimizes this scattering effect; scattering would therefore no longer be the spatial resolution limiting property of the material. The whole of medicine would benefit from such a detector. Disease could be diagnosed before symptoms develop using improved contrast and targeting. With increased speed of detection and improved image resolution patient comfort is increased and radiation dose decreased. The proposed project will produce experimental glass samples at the University of Paderborn in Germany; initial characterization will be done at Argonne National Laboratory (ANL) using Differential Scanning Calorimetry (DSC) and Raman Spectroscopy. The photoluminescence quantum efficiency and spatial resolution of the glasses will be measured at an Advanced Photon Source (APS) beam line and the read-out system will be engineered at Containerless Research Inc. (CRI) in Evanston, IL.

描述（由申请人提供）： 近年来，预防医学已被证明对健康是无价的。此外，机器和技术也有了许多发展，但“X射线”仍然是医疗诊断和疾病预防的主要手段。拟议的新能力将提高X射线探测的空间分辨率，并使许多疾病的诊断和治疗取得进展。分辨率的提高和读取的方便性只会有助于诊断问题的速度和细节。结合互补的成像方法，所提出的创新有可能提高对特定类型组织损伤的灵敏度。该研究的主要目标是使用相等或减少的X射线通量开发改进的空间成像，以这种方式，可以增加该技术的适用性。实际上，使用固态X射线检测器意味着可以很容易地将图像传输到计算机进行分析或存储，从而能够集成互补技术。当前的X射线光子存储材料（例如图像板）在其空间分辨率方面基本上受到在读出阶段中从所使用的多晶材料中的晶界散射的限制。这里提出的薄而透明的玻璃片成像最大限度地减少了这种散射效应;因此，散射将不再是材料的空间分辨率限制特性。整个医学界都将受益于这样一个探测器。使用改进的对比度和靶向，可以在症状出现之前诊断出疾病。随着检测速度的提高和图像分辨率的改善，患者的舒适度增加，辐射剂量降低。拟议项目将在德国帕德博恩大学生产实验玻璃样品;初步表征将在阿贡国家实验室（ANL）使用差示扫描量热法（DSC）和拉曼光谱法进行。玻璃的光致发光量子效率和空间分辨率将在先进光子源（APS）光束线上测量，读出系统将在Containerless Research Inc.设计。(CRI)埃文斯顿，IL。