ADVANCED HIGH-RESOLUTION TWO-DIMENSIONAL X-RAY DETECTOR

先进的高分辨率二维 X 射线探测器

• 批准号: 6734393
• 负责人: JACQUELINE A JOHNSON
• 金额: $ 25.94万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6734393
• 关键词: X ray; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; electromagnetic radiation; imaging /visualization /scanning; radiation detector; radiodiagnosis

DESCRIPTION (provided by applicant): In recent years preventative medicine has proved invaluable to health. In addition, there have been numerous developments in machines and techniques but the "x-ray" is still a staple in medical diagnosis and disease prevention. The proposed new capability will improve the spatial resolution for x-ray detection and allow advances in the diagnosis and treatment of numerous diseases. Improved resolution and ease of read-out can only help in the speed and detail with which a problem can be diagnosed. In combination with complementary imaging methods, the proposed innovation has the potential to increase sensitivity to specific types of tissue damage. A main goal of the research is to develop improved spatial imaging using equal or reduced x-ray fluxes, in this way, the applicability of the technique can be increased. Using, what is in effect a solid-state x-ray detector means that transferring images to computer for analysis or storage is readily accomplished, enabling complementary techniques to be integrated. Current x-ray photon storage materials such as image plates are fundamentally limited in their spatial resolution by scattering in the read-out stage from grain boundaries in the polycrystalline materials, which are used. Imaging with a thin and transparent glass sheet as proposed here minimizes this scattering effect; scattering would therefore no longer be the spatial resolution limiting property of the material. The whole of medicine would benefit from such a detector. Disease could be diagnosed before symptoms develop using improved contrast and targeting. With increased speed of detection and improved image resolution patient comfort is increased and radiation dose decreased. The proposed project will produce experimental glass samples at the University of Paderborn in Germany; initial characterization will be done at Argonne National Laboratory (ANL) using Differential Scanning Calorimetry (DSC) and Raman Spectroscopy. The photoluminescence quantum efficiency and spatial resolution of the glasses will be measured at an Advanced Photon Source (APS) beam line and the read-out system will be engineered at Containerless Research Inc. (CRI) in Evanston, IL.

描述（由申请人提供）： 近年来，事实证明预防医学对健康具有无价的价值。此外，机器和技术已经有了许多发展，但“X射线”仍然是医学诊断和疾病预防的主要手段。拟议的新功能将提高 X 射线检测的空间分辨率，并推动多种疾病的诊断和治疗取得进展。提高分辨率和易于读取只会有助于提高诊断问题的速度和细节。与补充成像方法相结合，所提出的创新有可能提高对特定类型组织损伤的敏感性。该研究的一个主要目标是使用相等或减少的X射线通量来开发改进的空间成像，这样可以提高该技术的适用性。使用实际上是固态 X 射线探测器意味着可以轻松地将图像传输到计算机进行分析或存储，从而能够集成互补技术。当前的X射线光子存储材料（例如图像板）由于在读出阶段从所使用的多晶材料的晶界散射，其空间分辨率从根本上受到限制。这里提出的使用薄而透明的玻璃板成像可以最大限度地减少这种散射效应；因此，散射将不再是材料的空间分辨率限制特性。整个医学界都将受益于这样的探测器。通过改进对比度和定位，可以在症状出现之前诊断出疾病。随着检测速度的提高和图像分辨率的提高，患者舒适度提高，辐射剂量降低。拟议项目将在德国帕德博恩大学生产实验玻璃样品；初步表征将在阿贡国家实验室 (ANL) 使用差示扫描量热法 (DSC) 和拉曼光谱进行。玻璃的光致发光量子效率和空间分辨率将在先进光子源 (APS) 光束线上进行测量，读出系统将在伊利诺伊州埃文斯顿的 Containerless Research Inc. (CRI) 进行设计。