ADVANCED HIGH-RESOLUTION TWO-DIMENSIONAL X-RAY DETECTOR FOR MAMMOGRAPHY

用于乳腺X线摄影的先进高分辨率二维X射线探测器

• 批准号: 8046190
• 负责人: JACQUELINE A JOHNSON
• 金额: $ 0.93万
• 依托单位: UNIVERSITY OF TENNESSEE SPACE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8046190
• 关键词: Affect; Animal Welfare; Benign; Bibliography; Bilateral; Breast; Breast Cancer Detection; Clinical; Country; Data; Developing Countries; Diagnosis; Diagnostic radiologic examination; Digital Mammography; Disincentive; Electronics; Environment; Environmental Impact; Equipment; Filtration; Future; Germany; Glass; Goals; Grant; Health Care Costs; IACUC; Image; International; Lasers; Light; Literature; Macor; Malignant - descriptor; Malignant Neoplasms; Mammography; Medical Technology; Noise; Principal Investigator; Productivity; Published Comment; Research; Research Ethics Committees; Research Infrastructure; Resolution; Resources; Sampling; Scanning; Scientist; Screening procedure; Structure; System; Techniques; Technology; Testing; Text; Time; United States; Vertebrates; Visit; Woman; abstracting; analog; base; calcification; cost; detector; digital; expiration; human subject; improved; malignant breast neoplasm; novel; premature; programs; radiologist; two-dimensional

The goal of this project is to improve the image quality and reduce the cost of digital mammography. We have assembled a multidisciplinary team to develop a computed radiography (CR) system for mammography based on novel glass ceramic materials. These glass materials can be less expensive and attain better performance than existing photostimulable phosphor materials. They are transparent and, therefore, do not suffer from loss of resolution and increase in noise due to light scattering from grain boundaries, as do polycrystalline materials. The proposed research builds on breakthrough results obtained in an R21 project titled "Advanced highresolution two-dimensional x-ray detector". The new work will result in the design and construction of a prototype device that will be used to demonstrate the feasibility of our approach. Specifically, we will: Optimize the glass phosphor materials for use in mammography based on analysis results from advanced microscopy, and spectroscopic techniques, along with synchrotron measurements made at the Advanced Photon Source. Characterize the resolution, contrast, and noise properties of the materials using typical mammography spectra. Develop a large-format glass phosphor, approximately 18 x 24 cm in size, suitable for mammography. Design and construct a prototype readout system. Characterize and benchmark the new CR system and compare it to an existing DR system using image quality metrics such as detective quantum efficiency. Finalize the design parameters for a system that could be used clinically. We believe that with our new glass phosphor system, higher quality digital mammograms can be obtained at a fraction of the cost of existing systems. This technology, in turn, would make digital mammography more accessible and could lead to improvements in the early detection of breast cancer.

该项目的目的是提高图像质量和 降低数字乳房X线摄影的成本。我们已经组建了一个多学科团队，以开发 基于新型玻璃陶瓷材料的乳房X线摄影的计算X线摄影系统（CR）系统。这些 玻璃材料可以比现有的光刺激性更便宜，并且获得性能更好 磷材料。它们是透明的，因此不会遭受解决方案的损失和 晶界的光散射引起的噪声增加，多晶材料也会增加。这 拟议的研究以R21项目为“高级高分辨率”的R21项目中获得的突破性结果为基础 二维X射线检测器”。新工作将导致设计和构建 原型设备将用于证明我们方法的可行性。具体来说，我们将： 根据分析结果优化用于乳房X线摄影的玻璃磷光材料 高级显微镜和光谱技术，以及在 高级光子源。表征分辨率，对比度和噪声特性 使用典型的乳腺摄影光谱材料。开发大幅面玻璃磷光器，大约 18 x 24厘米，适合乳房X线摄影。设计和构建原型读数系统。 表征和基准新的CR系统，并使用图像将其与现有的DR系统进行比较 质量指标，例如侦探量子效率。最终确定系统的设计参数 可以在临床上使用。我们相信，借助我们的新玻璃磷光系统，更高质量的数字 可以以现有系统成本的一小部分获得乳房X线照片。反过来，这项技术 将使数字乳房X线摄影更容易获得，并可能在早期改善 检测乳腺癌。