ADVANCED HIGH-RESOLUTION TWO-DIMENSIONAL X-RAY DETECTOR FOR MAMMOGRAPHY

该项目的目标是提高图像质量和 降低数字乳房X光检查的成本。我们已经组建了一个多学科团队来开发一种 基于新型玻璃陶瓷材料的计算机X线摄影(CR)系统。这些 玻璃材料可以比现有的光刺激材料更便宜，性能更好 荧光粉材料。它们是透明的，因此不会损失分辨率和 由于来自晶界的光散射而增加的噪声，多晶材料也是如此。这个 拟议的研究以R21项目中取得的突破性成果为基础，该项目名为“高级高分辨率” 这项新工作将导致设计和建造一个 将用来演示我们方法的可行性的原型装置。具体来说，我们会： 根据以下分析结果优化用于乳房X光检查的玻璃荧光粉材料 先进的显微镜和光谱技术，以及同步加速器测量 高级光子源。描述图像的分辨率、对比度和噪声属性 材料使用典型的乳房X光照相光谱。开发一种大尺寸玻璃荧光粉，大约 尺寸为18x24厘米，适合乳房X光摄影。设计并搭建了样机读出系统。 确定新CR系统的特征和基准，并将其与使用IMAGE的现有DR系统进行比较 检测量子效率等质量指标。最终确定系统的设计参数 可用于临床。我们相信，有了我们新的玻璃荧光粉系统，更高质量的数字 乳房X光检查的成本只有现有系统的一小部分。这项技术，反过来， 将使数字乳房X光检查更容易获得，并可能导致早期的改善 乳腺癌的检测。

The goal of this project is to improve the image quality and reduce the cost of digital mammography. We have assembled a multidisciplinary team to develop a computed radiography (CR) system for mammography based on novel glass ceramic materials. These glass materials can be less expensive and attain better performance than existing photostimulable phosphor materials. They are transparent and, therefore, do not suffer from loss of resolution and increase in noise due to light scattering from grain boundaries, as do polycrystalline materials. The proposed research builds on breakthrough results obtained in an R21 project titled "Advanced highresolution two-dimensional x-ray detector". The new work will result in the design and construction of a prototype device that will be used to demonstrate the feasibility of our approach. Specifically, we will: Optimize the glass phosphor materials for use in mammography based on analysis results from advanced microscopy, and spectroscopic techniques, along with synchrotron measurements made at the Advanced Photon Source. Characterize the resolution, contrast, and noise properties of the materials using typical mammography spectra. Develop a large-format glass phosphor, approximately 18 x 24 cm in size, suitable for mammography. Design and construct a prototype readout system. Characterize and benchmark the new CR system and compare it to an existing DR system using image quality metrics such as detective quantum efficiency. Finalize the design parameters for a system that could be used clinically. We believe that with our new glass phosphor system, higher quality digital mammograms can be obtained at a fraction of the cost of existing systems. This technology, in turn, would make digital mammography more accessible and could lead to improvements in the early detection of breast cancer.