ADVANCED HIGH-RESOLUTION TWO-DIMENSIONAL X-RAY DETECTOR FOR MAMMOGRAPHY

用于乳腺X线摄影的先进高分辨率二维X射线探测器

• 批准号: 8046190
• 负责人: JACQUELINE A JOHNSON
• 金额: $ 0.93万
• 依托单位: UNIVERSITY OF TENNESSEE SPACE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8046190
• 关键词: Affect; Animal Welfare; Benign; Bibliography; Bilateral; Breast; Breast Cancer Detection; Clinical; Country; Data; Developing Countries; Diagnosis; Diagnostic radiologic examination; Digital Mammography; Disincentive; Electronics; Environment; Environmental Impact; Equipment; Filtration; Future; Germany; Glass; Goals; Grant; Health Care Costs; IACUC; Image; International; Lasers; Light; Literature; Macor; Malignant - descriptor; Malignant Neoplasms; Mammography; Medical Technology; Noise; Principal Investigator; Productivity; Published Comment; Research; Research Ethics Committees; Research Infrastructure; Resolution; Resources; Sampling; Scanning; Scientist; Screening procedure; Structure; System; Techniques; Technology; Testing; Text; Time; United States; Vertebrates; Visit; Woman; abstracting; analog; base; calcification; cost; detector; digital; expiration; human subject; improved; malignant breast neoplasm; novel; premature; programs; radiologist; two-dimensional

The goal of this project is to improve the image quality and reduce the cost of digital mammography. We have assembled a multidisciplinary team to develop a computed radiography (CR) system for mammography based on novel glass ceramic materials. These glass materials can be less expensive and attain better performance than existing photostimulable phosphor materials. They are transparent and, therefore, do not suffer from loss of resolution and increase in noise due to light scattering from grain boundaries, as do polycrystalline materials. The proposed research builds on breakthrough results obtained in an R21 project titled "Advanced highresolution two-dimensional x-ray detector". The new work will result in the design and construction of a prototype device that will be used to demonstrate the feasibility of our approach. Specifically, we will: Optimize the glass phosphor materials for use in mammography based on analysis results from advanced microscopy, and spectroscopic techniques, along with synchrotron measurements made at the Advanced Photon Source. Characterize the resolution, contrast, and noise properties of the materials using typical mammography spectra. Develop a large-format glass phosphor, approximately 18 x 24 cm in size, suitable for mammography. Design and construct a prototype readout system. Characterize and benchmark the new CR system and compare it to an existing DR system using image quality metrics such as detective quantum efficiency. Finalize the design parameters for a system that could be used clinically. We believe that with our new glass phosphor system, higher quality digital mammograms can be obtained at a fraction of the cost of existing systems. This technology, in turn, would make digital mammography more accessible and could lead to improvements in the early detection of breast cancer.

该项目的目标是提高图像质量， 降低数字乳房X光检查的成本。我们组建了一个多学科团队， 基于新型玻璃陶瓷材料的乳腺X线摄影计算机X线摄影（CR）系统。这些 玻璃材料可以比现有的光激励材料更便宜并且获得更好的性能。 磷光体材料。它们是透明的，因此不会损失分辨率， 由于来自晶界的光散射而导致的噪声增加，多晶材料也是如此。的 拟议的研究建立在名为“高级高分辨率”的R21项目中获得的突破性成果之上 二维X射线探测器”。新的工作将导致设计和建造一个 原型设备，将用于证明我们的方法的可行性。具体而言，我们将： 根据以下分析结果优化乳腺X射线摄影中使用的玻璃荧光粉材料： 先进的显微镜和光谱技术，沿着同步加速器测量， 先进的光子源的分辨率、对比度和噪波属性 使用典型的乳房X射线照相术光谱的材料。开发大幅面玻璃荧光粉，大约 18 x 24 cm大小，适用于乳房X线摄影。设计并制作了一个原型读出系统。 对新CR系统进行表征和基准测试，并使用图像将其与现有DR系统进行比较 质量度量，例如检测量子效率。最后确定系统的设计参数， 可以用于临床。我们相信，我们的新的玻璃荧光粉系统，更高质量的数字 可以以现有系统的一小部分成本获得乳房X线照片。反过来，这项技术， 将使数字乳房X光检查更容易获得，并可能导致早期的改善， 乳腺癌的诊断