ADVANCED HIGH-RESOLUTION TWO-DIMENSIONAL X-RAY DETECTOR FOR MAMMOGRAPHY

用于乳腺X线摄影的先进高分辨率二维X射线探测器

• 批准号: 7991368
• 负责人: JACQUELINE A JOHNSON
• 金额: $ 36.48万
• 依托单位: UNIVERSITY OF TENNESSEE SPACE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7991368
• 关键词: Affect; Benchmarking; Benign; Bilateral; Breast; Breast Cancer Detection; Cereals; Clinical; Country; Data; Developing Countries; Diagnosis; Diagnostic radiologic examination; Differential Scanning Calorimetry; Digital Mammography; Disincentive; Electronics; Filtration; Future; Glass; Goals; Health Care Costs; Image; Investigation; Lasers; Light; Macor; Malignant - descriptor; Malignant Neoplasms; Mammography; Measures; Medical Technology; Noise; Performance; Principal Investigator; Productivity; Published Comment; Research; Research Infrastructure; Resolution; Roentgen Rays; Sampling; Scanning; Scanning Transmission Electron Microscopy Procedures; Screening procedure; Signal Transduction; Speed; Structure; System; Techniques; Technology; Testing; Text; Theoretical model; Time; United States; Woman; X ray diffraction analysis; X-Ray Diffraction; absorption; analog; base; calcification; cost; design; design and construction; detector; digital; improved; light scattering; luminescence; malignant breast neoplasm; novel; premature; programs; quantum; radiologist; response; two-dimensional

DESCRIPTION (provided by applicant): The goal of this project is to improve the image quality and reduce the cost of digital mammography. We will develop a computed radiography (CR) system for mammography based on novel glass ceramic materials. These glass materials can be less expensive and attain better performance than existing photostimulable phosphor materials. They are transparent and, therefore, do not suffer from loss of resolution and increase in noise due to light scattering from grain boundaries, as do polycrystalline materials. Specifically, we will: 1) Perform structural investigations via Differential Scanning Calorimetry, Scanning and Transmission Electron Microscopy, X-Ray Diffraction, Photoluminescence, X-ray excited Luminescence, and X-ray Absorption Near-Edge Structure. 2) Optimize the TSP material for the application in CR mammography: a) Improve the PSL signal, i.e. gain, of the TSP while maintaining high x-ray absorption and high resolution required for mammography. b) Minimize the stimulating exposure (laser power) required for readout. c) Minimize gain-fluctuation noise and structure noise in the TSP materials. d) Develop a large-format TSP plate for full-field digital mammography. 3) Design and construct a readout system for TSP. a) Design and build a benchtop readout apparatus. b) Determine design parameters and build a full-field, high-speed readout apparatus. 4) Characterize and benchmark the new computed radiography (CR) system by: a) Developing a theoretical model for the DQE of the TSP-based CR system. b) Measuring the system response, modulation transfer function (MTF), noise power spectra (NPS), noise equivalent quanta (NEQ), detective quantum efficiency (DQE), and contrast detail detectability of the new system. c) Measuring the system response, MTF, NPS, NEQ, DQE, and contrast detail detectability for a GE Essential FFDM system and FujiFilm CR mammography systems. d) Comparing the performance of the new system with the GE Essential and FujiFilm CR systems.

描述（由申请人提供）：本项目的目标是提高数字乳腺X射线摄影的图像质量并降低成本。我们将开发一种基于新型玻璃陶瓷材料的乳腺X射线计算机摄影（CR）系统。这些玻璃材料可以比现有的光激励磷光体材料更便宜并且获得更好的性能。它们是透明的，因此，不会像多晶材料那样由于晶界的光散射而损失分辨率和增加噪声。具体而言，我们将：1）通过差示扫描量热法、扫描和透射电子显微镜、X射线衍射、光致发光、X射线激发发光和X射线吸收近边结构进行结构研究。2)优化TSP材料在CR乳腺X射线摄影中的应用：a）改善TSP的PSL信号，即增益，同时保持乳腺X射线摄影所需的高X射线吸收和高分辨率。B）最小化读出所需的刺激暴露（激光功率）。c）最小化TSP材料中的增益波动噪声和结构噪声。d）开发用于全视野数字乳腺X射线摄影的大幅面TSP板。3)设计并构建了TSP的读出系统。a）设计并构建台式读出装置。B）确定设计参数并建立全场高速读出装置。4)通过以下方式对新型计算机X射线摄影（CR）系统进行表征和基准测试：a）为基于TSP的CR系统的DQE开发理论模型。B）测量新系统的系统响应、调制传递函数（MTF）、噪声功率谱（SNR）、噪声等效量子（NEQ）、量子探测效率（DQE）和对比度细节探测能力。c）测量GE Essential FFDM系统和FujiFilm CR乳腺X射线摄影系统的系统响应、MTF、SNR、NEQ、DQE和对比度细节可检测性。d）将新系统的性能与GE Essential和FujiFilm CR系统进行比较。

项目成果

Nanocrystallization in Fluorochlorozirconate Glass-Ceramics.

氟氯锆酸盐玻璃陶瓷的纳米结晶。

• DOI: 10.1111/jace.12540
• 发表时间: 2013
• 期刊: Journal of the American Ceramic Society. American Ceramic Society
• 作者: Alvarez,CarlosJ;Liu,Yuzi;Leonard,RussellL;Johnson,JacquelineA;Petford-Long,AmandaK
• 通讯作者: Petford-Long,AmandaK

The oxidation state of europium in halide glasses.

卤化物玻璃中铕的氧化态。

• DOI: 10.1088/0953-8984/23/49/495402
• 发表时间: 2011
• 期刊: Journal of physics. Condensed matter : an Institute of Physics journal
• 作者: Weber,JKR;Vu,M;Passlick,C;Schweizer,S;Brown,DE;Johnson,CE;Johnson,JA
• 通讯作者: Johnson,JA

Opportunities for Fluorochlorozirconate and Other Glass-Ceramic Detectors in Medical Imaging Devices.

• DOI: 10.19104/jbtr.2015.102
• 发表时间: 2015
• 期刊: Journal of biomedical technology and research
• 作者: Johnson JA;Leonard RL;Lubinsky AR;Schweizer S
• 通讯作者: Schweizer S

Paramagnetic hyperfine splitting in the Eu Mössbauer spectra of CaF(2):Eu.

CaF(2):Eu 的 Eu 穆斯堡尔谱中的顺磁超精细分裂。

• DOI: 10.1103/physrevb.77.224442
• 发表时间: 2008
• 期刊: Physical review. B, Condensed matter and materials physics
• 作者: Selling,J;Bielemeier,B;Wortmann,G;Johnson,JA;Alp,EE;Chen,T;Brown,DE;Johnson,CE;Schweizer,S
• 通讯作者: Schweizer,S

Structural properties of fluorozirconate-based glass ceramics doped with multivalent europium.

多价铕掺杂氟锆酸盐基玻璃陶瓷的结构性能

• DOI: 10.1063/1.3662148
• 发表时间: 2011
• 期刊: Journal of applied physics
• 影响因子: 3.2
• 作者: Paßlick,C;Müller,O;Lützenkirchen-Hecht,D;Frahm,R;Johnson,JA;Schweizer,S
• 通讯作者: Schweizer,S