ADVANCED HIGH-RESOLUTION TWO-DIMENSIONAL X-RAY DETECTOR FOR MAMMOGRAPHY

用于乳腺X线摄影的先进高分辨率二维X射线探测器

• 批准号: 7991368
• 负责人: JACQUELINE A JOHNSON
• 金额: $ 36.48万
• 依托单位: UNIVERSITY OF TENNESSEE SPACE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7991368
• 关键词: Affect; Benchmarking; Benign; Bilateral; Breast; Breast Cancer Detection; Cereals; Clinical; Country; Data; Developing Countries; Diagnosis; Diagnostic radiologic examination; Differential Scanning Calorimetry; Digital Mammography; Disincentive; Electronics; Filtration; Future; Glass; Goals; Health Care Costs; Image; Investigation; Lasers; Light; Macor; Malignant - descriptor; Malignant Neoplasms; Mammography; Measures; Medical Technology; Noise; Performance; Principal Investigator; Productivity; Published Comment; Research; Research Infrastructure; Resolution; Roentgen Rays; Sampling; Scanning; Scanning Transmission Electron Microscopy Procedures; Screening procedure; Signal Transduction; Speed; Structure; System; Techniques; Technology; Testing; Text; Theoretical model; Time; United States; Woman; X ray diffraction analysis; X-Ray Diffraction; absorption; analog; base; calcification; cost; design; design and construction; detector; digital; improved; light scattering; luminescence; malignant breast neoplasm; novel; premature; programs; quantum; radiologist; response; two-dimensional

DESCRIPTION (provided by applicant): The goal of this project is to improve the image quality and reduce the cost of digital mammography. We will develop a computed radiography (CR) system for mammography based on novel glass ceramic materials. These glass materials can be less expensive and attain better performance than existing photostimulable phosphor materials. They are transparent and, therefore, do not suffer from loss of resolution and increase in noise due to light scattering from grain boundaries, as do polycrystalline materials. Specifically, we will: 1) Perform structural investigations via Differential Scanning Calorimetry, Scanning and Transmission Electron Microscopy, X-Ray Diffraction, Photoluminescence, X-ray excited Luminescence, and X-ray Absorption Near-Edge Structure. 2) Optimize the TSP material for the application in CR mammography: a) Improve the PSL signal, i.e. gain, of the TSP while maintaining high x-ray absorption and high resolution required for mammography. b) Minimize the stimulating exposure (laser power) required for readout. c) Minimize gain-fluctuation noise and structure noise in the TSP materials. d) Develop a large-format TSP plate for full-field digital mammography. 3) Design and construct a readout system for TSP. a) Design and build a benchtop readout apparatus. b) Determine design parameters and build a full-field, high-speed readout apparatus. 4) Characterize and benchmark the new computed radiography (CR) system by: a) Developing a theoretical model for the DQE of the TSP-based CR system. b) Measuring the system response, modulation transfer function (MTF), noise power spectra (NPS), noise equivalent quanta (NEQ), detective quantum efficiency (DQE), and contrast detail detectability of the new system. c) Measuring the system response, MTF, NPS, NEQ, DQE, and contrast detail detectability for a GE Essential FFDM system and FujiFilm CR mammography systems. d) Comparing the performance of the new system with the GE Essential and FujiFilm CR systems.

描述（由申请人提供）：该项目的目的是提高图像质量并降低数字乳房X线摄影的成本。我们将基于新型玻璃陶瓷材料开发用于乳房X线摄影的计算X线摄影系统。这些玻璃材料比现有的可刺激性磷光材料可以更便宜，并且具有更好的性能。它们是透明的，因此，由于晶界的光散射，分辨率损失和噪声增加，多晶材料也不遭受噪声的增加。具体而言，我们将：1）通过差分扫描量热法，扫描和透射电子显微镜，X射线衍射，光致发光，X射线激发发光和X射线吸收接近边缘结构进行结构研究。 2）优化在CR乳房X线摄影中应用的TSP材料：a）改善PSL信号，即TSP的增益，同时保持乳房X线摄影所需的高X射线吸收和高分辨率。 b）最大程度地减少读数所需的刺激性暴露（激光功率）。 c）最小化TSP材料中的增益 - 透明噪声和结构噪声。 d）开发一个大型TSP板，用于全场数字乳房X线摄影。 3）为TSP设计和构建一个读数系统。 a）设计和构建台式读数设备。 b）确定设计参数并构建一个全面的高速读数设备。 4）对新计算的射线照相系统（CR）系统进行表征和基准测试：a）为基于TSP的CR系统的DQE开发理论模型。 b）测量系统响应，调制传输函数（MTF），噪声功率谱（NP），噪声等效量子（NEQ），侦探量子效率（DQE）和新系统的对比度细节可检测性。 c）测量系统响应，MTF，NP，NEQ，DQE以及GE ESSENSION FFDM系统和Fujifilm CR X线X线摄影系统的对比度可检测性。 d）将新系统的性能与GE Essential和Fujifilm CR系统进行比较。

项目成果

Nanocrystallization in Fluorochlorozirconate Glass-Ceramics.

氟氯锆酸盐玻璃陶瓷的纳米结晶。

• DOI: 10.1111/jace.12540
• 发表时间: 2013
• 期刊: Journal of the American Ceramic Society. American Ceramic Society
• 作者: Alvarez,CarlosJ;Liu,Yuzi;Leonard,RussellL;Johnson,JacquelineA;Petford-Long,AmandaK
• 通讯作者: Petford-Long,AmandaK

The oxidation state of europium in halide glasses.

卤化物玻璃中铕的氧化态。

• DOI: 10.1088/0953-8984/23/49/495402
• 发表时间: 2011
• 期刊: Journal of physics. Condensed matter : an Institute of Physics journal
• 作者: Weber,JKR;Vu,M;Passlick,C;Schweizer,S;Brown,DE;Johnson,CE;Johnson,JA
• 通讯作者: Johnson,JA

Opportunities for Fluorochlorozirconate and Other Glass-Ceramic Detectors in Medical Imaging Devices.

• DOI: 10.19104/jbtr.2015.102
• 发表时间: 2015
• 期刊: Journal of biomedical technology and research
• 作者: Johnson JA;Leonard RL;Lubinsky AR;Schweizer S
• 通讯作者: Schweizer S

Paramagnetic hyperfine splitting in the Eu Mössbauer spectra of CaF(2):Eu.

CaF(2):Eu 的 Eu 穆斯堡尔谱中的顺磁超精细分裂。

• DOI: 10.1103/physrevb.77.224442
• 发表时间: 2008
• 期刊: Physical review. B, Condensed matter and materials physics
• 作者: Selling,J;Bielemeier,B;Wortmann,G;Johnson,JA;Alp,EE;Chen,T;Brown,DE;Johnson,CE;Schweizer,S
• 通讯作者: Schweizer,S

Structural properties of fluorozirconate-based glass ceramics doped with multivalent europium.

多价铕掺杂氟锆酸盐基玻璃陶瓷的结构性能

• DOI: 10.1063/1.3662148
• 发表时间: 2011
• 期刊: Journal of applied physics
• 影响因子: 3.2
• 作者: Paßlick,C;Müller,O;Lützenkirchen-Hecht,D;Frahm,R;Johnson,JA;Schweizer,S
• 通讯作者: Schweizer,S