UNC-CH CENTER FOR ENVIRONMENTAL HEALTH & SUSCEPTIBILITY

本申请建议在北卡罗来纳大学(UNC)教堂山分校公共卫生学院的NIEHS环境健康科学中心补助金(P30)计划下建立一个中心。这个“北卡罗来纳大学--CHC环境健康和敏感性中心”的重点是环境流行病学和毒理学领域。三个研究核心将构成该中心的智力核心，围绕以下集中领域组织：遗传敏感性，汇集实验室和分子流行病学对易感性决定因素的研究；发育敏感性，研究生命周期中不同阶段的作用以及这些作用如何影响暴露易感性，特别关注从怀孕到儿童时期的暴露；毒动力敏感性，重新审查导致对外部因素反应范围广泛的生理和代谢因素的个体间变异性。四个设施核心将提供关键服务，并将为中心调查人员带来成本效益：高通量基因分型、生物统计学和流行病学方法、生物标记物和营养评估。行政核心将负责协调中心的活动、战略规划和评估：试点项目计划；成员决定；财务事务；北卡罗来纳大学-CH的环境健康研究的领导力和知名度。社区教育和外联方案将协助行政核心向专业人员、媒体和广大公众宣传和教育与中心有关的环境健康主题，重点是北卡罗来纳州，并将促进科学家/公民的双向互动。该中心旨在最大限度地促进跨学科整合，以促进具有令人兴奋的科学潜力的新研究合作，了解化学毒性的机制基础，并有效减少环境相关疾病的负担。

This application proposes to establish a Center under the NIEHS Environmental Health Sciences Center Grants (P30) program in the School of Public Health, at the University of North Carolina (UNC), Chapel Hill. The focus of this "UNC-CH Center on Environmental Health and Susceptibility" is in the area of environmental epidemiology and toxicology. Three research cores will form the intellectual heart of the Center, organized around the following areas of concentration: Genetic Susceptibility, bringing together laboratory and molecular epidemiologic research on genomic determinants of susceptibility; Developmental Susceptibility, addressing the role of different stages in the life cycle and how these influence susceptibility to exposure, with a particular concentration on exposures received from conception through childhood; and Toxicokinetic Susceptibility, reexamining inter-individual variability in physiologic and metabolic factors that are responsible for the wide ranges in response to an exogenous agent. Four facility cores will provide critical services and will result in cost-efficiency for Center investigators: High Throughput Genotyping, Biostatistics and Epidemiologic Methods, Biomarkers, and Nutrient Assessment. The Administrative Core will have responsibility for coordination of Center activities, strategic planning and evaluation: the Pilot Projects Program; membership decisions; financial matters; leadership and visibility for UNC-CH's environmental health research. The Community Education and Outreach Program will assist the Administrative Core in dissemination and education about Center- related themes on environmental health to professionals, the media, and the public at large, with a focus on the state of North Carolina, and will promote two-way scientist/citizen interactions. This Center is designed to maximize cross-disciplinary integration to promote new research collaborations with exciting scientific potential, understand the mechanistic basis of chemical toxicity, and effectively reduce the burden of environmentally-related disease.