UNC-CH CENTER FOR ENVIRONMENTAL HEALTH & SUSCEPTIBILITY

北卡罗来纳大学教堂山环境健康和易感性中心带来了人口科学， 医学和生物医学研究人员一起研究环境健康中的主要问题，这些问题是由影响个人对疾病易感性的基因环境相互作用引起的。这种相互作用的高度复杂性需要许多不同学科的深入专业知识，以了解遗传，代谢，内分泌，发育和毒理学问题对疾病结果的影响。该提案寻求核心支持，通过促进研究人员之间的互动与合作来实现这一目标，以便环境卫生各个领域的专家的专门知识能够扩大杰出研究人员队伍的视野和能力，使其远远超出规范。这种互动和合作已经在前三年的支持中得到了证明，并将在五个研究核心中继续下去：遗传易感性，发育易感性，毒代动力学易感性，transomics和肥胖研究。核心支持还将通过四个设施核心的支持，为我们的科学家提供最先进的资源和专业知识。分子流行病学将为生物标本提供集中资源 收集、制备、储存和跟踪以及高通量遗传分析。 生物统计学和流行病学方法将提供统计和研究设计和分析方面的咨询，以帮助确保我们的环境健康研究得出有效的科学结论。生物标记核心提供培训，专业知识和样品分析，使用昂贵和复杂的仪器进行质谱，分子生物学，基因组学，蛋白质组学和代谢组学。最后，营养评估核心将提供营养分析和膳食评估以及可能调节环境健康和疾病的营养状况生物标志物。核心支持还为多方面的试点项目计划提供资金，该计划促进跨学科合作，鼓励年轻的研究人员进入环境健康研究，并提高设施核心的使用。此外，所请求的支持将提供多样化的浓缩方案，这将增加与来访调查人员的互动，并扩大环境健康的范围 research.对社区外展和教育计划的支持将促进翻译 将中心的科学进步传达给非专业社区、相关公民团体和政府的活动。NIEHS卓越中心将由一个行政核心协调，该核心通过北卡罗来纳州大学公共卫生学院进行报告。

The UNC-Chapel Hill Center for Environmental Health and Susceptibility brings population science, medical and biomedical researchers together to examine major issues in environmental health resulting from gene environment interactions that affect an individual's susceptibility to disease. The highly complex nature of such interactions demands in-depth expertise in many different disciplines to understand the influence of genetic, metabolic, endocrine, developmental and toxicological issues on disease outcomes. This proposal seeks core support to achieve this goal by fostering enhanced interaction and collaboration among researchers, so that the expertise of experts in diverse fields of environmental health can expand the vision and capabilities of a preeminent cadre of researchers to excel far beyond the norm. Such interaction and collaboration has been demonstrated during the first three years of support and will continue among the five research cores: Genetic Susceptibility, Developmental Susceptibility, Toxicokinetic Susceptibility, Transomics, and Obesity Research. The core support will also make state-of-the-art resources and expertise available to our scientists through the support of four facility cores. Molecular Epidemiology will provide centralized resources for biospecimen collection, preparation, storage and tracking, and high throughput genetic analysis. Biostatistical and Epidemiologic Methods will provide consultation on statistical and study design and analysis to help ensure that valid scientific conclusions emerge from our environmental health research. The Biomarkers core makes available training, expertise and sample analysis using expensive and sophisticated instrumentation for mass spectrometry, molecular biology, genomics, proteomics and metabolomics. Finally, the Nutrient Assessment core will supply analysis and dietary assessment of nutrients and biomarkers of nutritional status that may modulate environmental health and disease. The core support also provides funds for a multifaceted Pilot Project Program that promotes interdisciplinary collaboration, encourages young investigators to enter environmental health research, and enhances use of the facility cores. In addition, the requested support will provide a diverse enrichment program that will increase interactions with visiting investigators and broaden the scope of environmental health research. Support for a Community Outreach and Education Program will facilitate translational activities that communicate the scientific advances of the Center to the lay community, concerned citizens groups, and government. This NIEHS Center of Excellence will be coordinated by an Administrative core that reports through the School of Public Health at the University of North Carolina.