ENVIRONMENTAL EXPOSURE AND EFFECT OF HAZARDOUS CHEMICALS

危险化学品的环境暴露和影响

• 批准号: 7916290
• 负责人: JAMES A SWENBERG
• 金额: $ 22.2万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-10 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916290
• 关键词: ENVIRONMENTAL; EXPOSURE; EFFECT; HAZARDOUS; CHEMICALS

DESCRIPTION (provided by applicant) The primary objective of the NIEHS Superfund Basic Research Program (SBRP) is to understand the human health and environmental risks associated with hazardous waste sites, with the goal of more accurately assessing risks and more efficiently remediating hazardous waste sites. Since its inception, the UNC SBRP has focused its multidisciplinary research on addressing scientific issues that underpin the assessment of human risk and the development of improved methods for remediation of hazardous waste sites, in the proposed research, we will further advance this goal through the following objectives: 1) apply new molecular and analytical tools in a systems biology framework to understand critical pathways for environmental disease and bioremediation; 2) develop biomarkers of exposure and effect for humans and experimental models of environmental disease; 3) use this knowledge to elucidate the modes of action for major chlorinated hydrocarbons and polycyclic aromatic hydrocarbons; 4) examine the effects of dose-response on such modes of action; 5) evaluate and understand genetic susceptibility to hazardous chemicals; 6) determine the factors controlling dermal absorption of polycyclic aromatic hydrocarbons and the relationship of internal dose to both skin and systemic exposure; and 7) develop and evaluate remediation methods in complex, field-relevant systems for their potential to reduce overall human exposures and risks. These objectives will be accomplished through six diverse, but highly interdigitated research projects, two research support cores, a research translation core, a training core and an administrative core.

描述（由申请人提供） NIEHS超级基础研究计划（SBRP）的主要目标是了解与危险废物站点相关的人类健康和环境风险，目的是更准确地评估风险并更有效地修复有害的废物站点。自成立以来，UNC SBRP已将其多学科研究集中在解决人类风险评估的科学问题上，并开发了改进的方法来补救危险废物站点，在拟议的研究中，我们将进一步促进这一目标，通过以下目标促进这一目标：1）在系统的生物学框架中应用新的分子和分析工具，以了解系统的生物学框架，并了解环境疾病的范围，并将其用于becoriation; 2）发展对人类的暴露和影响的生物标志物以及环境疾病的实验模型； 3）使用这些知识来阐明主要的氯化碳氢化合物和多环芳烃的作用模式； 4）检查剂量反应对这种作用方式的影响； 5）评估和了解对危险化学物质的遗传敏感性； 6）确定控制多环芳烃皮肤吸收的因素以及内部剂量与皮肤和全身暴露的关系； 7）在复杂的，与现场相关的系统中开发和评估补救方法，以减少整体人类暴露和风险的潜力。这些目标将通过六个不同但高度相互互动的研究项目，两个研究支持核心，研究翻译核心，培训核心和行政核心来实现。