ENVIRONMENTAL EXPOSURE AND EFFECT OF HAZARDOUS CHEMICALS

危险化学品的环境暴露和影响

• 批准号: 7916289
• 负责人: JAMES A SWENBERG
• 金额: $ 22.2万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-06 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916289
• 关键词: ENVIRONMENTAL; EXPOSURE; EFFECT; HAZARDOUS; CHEMICALS

DESCRIPTION (provided by applicant) The primary objective of the NIEHS Superfund Basic Research Program (SBRP) is to understand the human health and environmental risks associated with hazardous waste sites, with the goal of more accurately assessing risks and more efficiently remediating hazardous waste sites. Since its inception, the UNC SBRP has focused its multidisciplinary research on addressing scientific issues that underpin the assessment of human risk and the development of improved methods for remediation of hazardous waste sites, in the proposed research, we will further advance this goal through the following objectives: 1) apply new molecular and analytical tools in a systems biology framework to understand critical pathways for environmental disease and bioremediation; 2) develop biomarkers of exposure and effect for humans and experimental models of environmental disease; 3) use this knowledge to elucidate the modes of action for major chlorinated hydrocarbons and polycyclic aromatic hydrocarbons; 4) examine the effects of dose-response on such modes of action; 5) evaluate and understand genetic susceptibility to hazardous chemicals; 6) determine the factors controlling dermal absorption of polycyclic aromatic hydrocarbons and the relationship of internal dose to both skin and systemic exposure; and 7) develop and evaluate remediation methods in complex, field-relevant systems for their potential to reduce overall human exposures and risks. These objectives will be accomplished through six diverse, but highly interdigitated research projects, two research support cores, a research translation core, a training core and an administrative core.

描述（由申请人提供） NIEHS超级基金基础研究计划（SBRP）的主要目标是了解与危险废物场地相关的人类健康和环境风险，目的是更准确地评估风险，更有效地补救危险废物场地。自成立以来，联合国环境、生物和自然资源保护研究计划一直将其多学科研究的重点放在解决科学问题上，这些问题是评估人类风险和开发改进的危险废物场地补救方法的基础，在拟议的研究中，我们将通过以下目标进一步推进这一目标：1）在系统生物学框架中应用新的分子和分析工具，以了解环境疾病和生物修复的关键途径; 2）开发人类接触和影响的生物标志物和环境疾病的实验模型; 3）利用这一知识阐明主要氯化碳氢化合物和多环芳烃的作用模式; 4）研究剂量-反应对这些作用模式的影响; 5）评估和了解危险化学品的遗传易感性; 6）确定控制皮肤吸收多环芳烃的因素以及体内剂量与皮肤和全身接触的关系;以及7）制定和评价复杂的、与实地有关的系统中的补救方法，以确定其减少人类总体接触和风险的潜力。这些目标将通过六个不同但高度相互交叉的研究项目、两个研究支助核心、一个研究翻译核心、一个培训核心和一个行政核心来实现。