Characterizing MRI parameters of iron-loaded tissues

表征含铁组织的 MRI 参数

• 批准号: 6803463
• 负责人: MARK D DOES
• 金额: $ 37.75万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-20 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803463
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomagnetism measurement; disease /disorder model; iron disorder; iron metabolism; iron poisoning; iron storage disorder; laboratory rat; magnetic resonance imaging; method development; noninvasive diagnosis; nuclear magnetic resonance spectroscopy; relaxation spectrometry; superconductivity

DESCRIPTION (provided by applicant): The overall aims of this project are to understand quantitatively the relationships between tissue iron levels and nuclear magnetic resonance (NMR) properties in order to develop a method for rigorously measuring iron in the brain, liver, and other organs. Iron is a physiologically vital substance, but it also can be toxic and has been associated with numerous pathological states in various tissues. As summarized in the report of a recent NIDDK workshop, the only established, calibrated method for non-invasive measurement of tissue iron stores is currently biomagnetic susceptometry using Superconducting Quantum Interference Device (SQUID) magnetometers, but the cost, complexity, and technical demands limit access to this technique. Many previous studies have indicated that magnetic resonance imaging (MRI) can detect iron loading, but no clear protocol has been established to measure iron content in tissue accurately. While NMR can readily detect a variety of signal parameters that depend upon the iron content of tissue, the exact dependence of these parameters (e.g. T1, T2, T2*, T2', delta/omega on the concentration and form of the stored iron is complex and unclear. This problem can be addressed only by combining studies of iron metabolism with studies of fundamental nuclear relaxation mechanisms and the development of advanced MRI measurement protocols. Our group at Vanderbilt is uniquely qualified for such an approach. We propose to combine the study of an animal model of iron overload, advanced NMR techniques, and high-resolution SQUID susceptibility imaging. These experiments, in combination with computer simulations, will allow the detailed, quantitative comparison of biomagnetic and NMR data from individual animals whose tissue iron content can be determined quantitatively at the end of each experiment

描述（由申请人提供）： 该项目的总体目的是定量地了解组织铁水平与核磁共振（NMR）特性之间的关系，以开发一种严格测量大脑，肝脏和其他器官中铁的方法。铁是一种生理上重要的物质，但也可能是有毒的，并且与各种组织中的许多病理状态有关。正如最近的NIDDK研讨会的报告中总结的那样，目前使用超导量子干扰装置（Squid）磁力计的唯一已建立的，校准的，无创测量组织铁储存的方法是生物磁性苏联，但是成本，复杂性和技术需求限制了该技术的限制。许多先前的研究表明，磁共振成像（MRI）可以检测到铁负荷，但是尚未建立明确的方案来准确测量组织中的铁含量。虽然NMR可以轻松地检测到依赖于组织的铁含量的各种信号参数，但这些参数的确切依赖性（例如T1，T1，T2，T2，T2*，T2，T2'，Delta/Omega对存储的铁的浓度和形式的浓度和形式是复杂而不清楚的。仅通过将其发展的机构与核心的核能结合来解决。我们在范德比尔特（Vanderbilt）的群体具有独特的资格，我们建议将铁超载的动物模型，高级NMR技术和高分辨率的元素组合在一起，并结合这些实验的成像。