Bioresorbable RF Coils For Post-Surgical Monitoring by MRI

用于术后 MRI 监测的生物可吸收射频线圈

• 批准号: 9896142
• 负责人: MARK D DOES
• 金额: $ 21.53万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9896142
• 关键词: Animals; Cadaver; Caliber; Clinical; Clinical Research; Connective Tissue; Coupling; Crush Injury; Devices; Diagnostic; Edema; Electronics; Evaluation; Gel; Geometry; Goals; Heterogeneity; Human; Image; Image Analysis; Implant; Intervention; Location; Longevity; Magnetic Resonance Imaging; Measures; Metals; Monitor; Motor; Muscular Atrophy; Natural regeneration; Nerve; Nerve Regeneration; Noise; Operative Surgical Procedures; Outcome; Performance; Peripheral Nerves; Peripheral nerve injury; Positioning Attribute; Procedures; Process; Rattus; Recovery of Function; Reporting; Research Design; Resolution; Second Look Surgery; Series; Signal Transduction; Structure; Surface; Surgeon; Technology; Testing; Time; Tissues; Traumatic injury; Wireless Technology; Work; arm; base; clinical application; clinical diagnostics; clinical translation; design; functional loss; high resolution imaging; imaging study; imaging system; in silico; in vivo; injury and repair; interest; minimally invasive; nerve injury; peripheral nerve regeneration; preclinical study; radio frequency; reinnervation; repaired; research clinical testing; response; sciatic nerve; tool

PROJECT SUMMARY/ABSTRACT The overarching goal of this project is to develop and evaluate implantable and bioresorbable radio frequency (RF) coils for high-resolution and high-specicity post-surgical monitoring with magnetic resonance imaging (MRI). The immediate target application of this work is the evaluation of peripheral nerve regeneration following surgical repair. Surgical repair of nerve is common following traumatic injury, but outcomes are highly variable. MRI oers potential to monitor response of the nerve to surgical repair; however, it can be a challenge to acquire MRI with sucient spatial resolution and signal-to-noise ratio (SNR) for robust characterization of nerve regeneration. The use of a small, local RF coil for MRI signal reception is known to substantially increase SNR and enable higher image resolution over a targeted volume of tissue. Such coils have been demonstrated eective in animal studies and here we propose to harness recent advances in bioresorbable electronics technology to create biore- sorbable RF coils that are suitable for clinical applications. Specically, we will develop and evaluate coils for the purpose of quantitatively evaluating nerve regeneration following surgical repair. In aim 1, we will design and fabricate a wide range of dierent bioresorbable RF coils, suitable imaging nerves of dierent sizes and locations. In aim 2, we will experimentally test these coils in normal rats, rats that have undergone an experimental nerve injury, and in human cadaver arms.

项目摘要/摘要 该项目的总体目标是开发和评估可植入和生物吸收的射频 （RF）用于高分辨率和高特定后手术后监测的线圈和磁共振成像 （MRI）。这项工作的直接目标应用是对外周神经再生的评估 手术修复。神经的手术修复是创伤性损伤后常见的，但结果却高度可变。 MRI OERS可能监测神经对手术修复的反应；但是，这可能是一个挑战 以鲁棒的神经表征获取以空间分辨率和信噪比（SNR）获得的MRI 再生。 已知使用小的局部RF线圈用于MRI信号接收会大大增加SNR并启用 较高的图像分辨率在目标体积的组织上。此类线圈已在动物中表现出来 研究和在这里我们建议利用可生物吸收电子技术的最新进展，以创建生物味 - 适合临床应用的可吸附的RF线圈。具体而言，我们将开发和评估线圈 手术修复后定量评估神经再生的目的。在AIM 1中，我们将设计和 制造各种二种生物可吸收的RF线圈，合适的尺寸和位置的成像神经。 在AIM 2中，我们将通过实验性大鼠进行实验测试这些线圈的大鼠，这些大鼠经历了实验性神经 受伤，在人类的尸体臂中。