Bioresorbable RF Coils For Post-Surgical Monitoring by MRI

用于术后 MRI 监测的生物可吸收射频线圈

• 批准号: 9896142
• 负责人: MARK D DOES
• 金额: $ 21.53万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2022-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9896142
• 关键词: Animals; Cadaver; Caliber; Clinical; Clinical Research; Connective Tissue; Coupling; Crush Injury; Devices; Diagnostic; Edema; Electronics; Evaluation; Gel; Geometry; Goals; Heterogeneity; Human; Image; Image Analysis; Implant; Intervention; Location; Longevity; Magnetic Resonance Imaging; Measures; Metals; Monitor; Motor; Muscular Atrophy; Natural regeneration; Nerve; Nerve Regeneration; Noise; Operative Surgical Procedures; Outcome; Performance; Peripheral Nerves; Peripheral nerve injury; Positioning Attribute; Procedures; Process; Rattus; Recovery of Function; Reporting; Research Design; Resolution; Second Look Surgery; Series; Signal Transduction; Structure; Surface; Surgeon; Technology; Testing; Time; Tissues; Traumatic injury; Wireless Technology; Work; arm; base; clinical application; clinical diagnostics; clinical translation; design; functional loss; high resolution imaging; imaging study; imaging system; in silico; in vivo; injury and repair; interest; minimally invasive; nerve injury; peripheral nerve regeneration; preclinical study; radio frequency; reinnervation; repaired; research clinical testing; response; sciatic nerve; tool

PROJECT SUMMARY/ABSTRACT The overarching goal of this project is to develop and evaluate implantable and bioresorbable radio frequency (RF) coils for high-resolution and high-specicity post-surgical monitoring with magnetic resonance imaging (MRI). The immediate target application of this work is the evaluation of peripheral nerve regeneration following surgical repair. Surgical repair of nerve is common following traumatic injury, but outcomes are highly variable. MRI oers potential to monitor response of the nerve to surgical repair; however, it can be a challenge to acquire MRI with sucient spatial resolution and signal-to-noise ratio (SNR) for robust characterization of nerve regeneration. The use of a small, local RF coil for MRI signal reception is known to substantially increase SNR and enable higher image resolution over a targeted volume of tissue. Such coils have been demonstrated eective in animal studies and here we propose to harness recent advances in bioresorbable electronics technology to create biore- sorbable RF coils that are suitable for clinical applications. Specically, we will develop and evaluate coils for the purpose of quantitatively evaluating nerve regeneration following surgical repair. In aim 1, we will design and fabricate a wide range of dierent bioresorbable RF coils, suitable imaging nerves of dierent sizes and locations. In aim 2, we will experimentally test these coils in normal rats, rats that have undergone an experimental nerve injury, and in human cadaver arms.

项目概要/摘要 该项目的总体目标是开发和评估可植入和生物可吸收射频 (RF) 线圈，用于通过磁共振成像进行高分辨率和高特异性术后监测 （核磁共振成像）。这项工作的直接目标应用是评估周围神经再生 手术修复。神经外科修复在创伤性损伤后很常见，但结果差异很大。 MRI 有潜力监测神经对手术修复的反应；然而，这可能是一个挑战 获取具有足够空间分辨率和信噪比 (SNR) 的 MRI，以实现神经的稳健表征 再生。 众所周知，使用小型局部射频线圈进行 MRI 信号接收可以显着提高 SNR，并能够 目标组织体积上具有更高的图像分辨率。这种线圈已被证明在动物身上有效 研究，在这里我们建议利用生物可吸收电子技术的最新进展来创造生物可吸收 适合临床应用的可吸附射频线圈。具体来说，我们将开发和评估线圈 定量评估手术修复后神经再生的目的。在目标 1 中，我们将设计并 制造各种不同的生物可吸收射频线圈，适合不同尺寸和位置的成像神经。 在目标 2 中，我们将在正常大鼠、接受过实验性神经刺激的大鼠中对这些线圈进行实验测试 伤害，以及人类尸体手臂。