Bioresorbable RF Coils For Post-Surgical Monitoring by MRI

项目摘要/摘要 该项目的首要目标是开发和评估可植入和可生物吸收的无线电频率。 用于高分辨率和高特异性磁共振成像术后监测的(RF)线圈 (核磁共振)。这项工作的直接目标应用是评估术后周围神经再生 外科修复。创伤后手术修复神经是常见的，但结果是高度不确定的。 核磁共振在监测神经对手术修复的反应方面具有潜力；然而，它可能是一个挑战 获得具有良好空间分辨率和信噪比(SNR)的MRI，以便对神经进行稳健的表征 再生。 已知使用小的本地RF线圈来接收MRI信号可显著提高SNR并使 在目标组织体积上获得更高的图像分辨率。这种线圈已经在动物身上证明是有效的 在这里，我们建议利用生物可再吸收电子技术的最新进展来创造生物矿藏- 适合临床应用的可吸收射频线圈。具体地说，我们将开发和评估 目的：定量评价神经修复术后神经再生情况。在目标1中，我们将设计和 制作各种不同的生物可吸收射频线圈，适合不同大小和位置的成像神经。 在目标2中，我们将在正常大鼠身上对这些线圈进行实验测试，这些大鼠经历了实验神经 伤痕累累，在人类身体的手臂上。

PROJECT SUMMARY/ABSTRACT The overarching goal of this project is to develop and evaluate implantable and bioresorbable radio frequency (RF) coils for high-resolution and high-specicity post-surgical monitoring with magnetic resonance imaging (MRI). The immediate target application of this work is the evaluation of peripheral nerve regeneration following surgical repair. Surgical repair of nerve is common following traumatic injury, but outcomes are highly variable. MRI oers potential to monitor response of the nerve to surgical repair; however, it can be a challenge to acquire MRI with sucient spatial resolution and signal-to-noise ratio (SNR) for robust characterization of nerve regeneration. The use of a small, local RF coil for MRI signal reception is known to substantially increase SNR and enable higher image resolution over a targeted volume of tissue. Such coils have been demonstrated eective in animal studies and here we propose to harness recent advances in bioresorbable electronics technology to create biore- sorbable RF coils that are suitable for clinical applications. Specically, we will develop and evaluate coils for the purpose of quantitatively evaluating nerve regeneration following surgical repair. In aim 1, we will design and fabricate a wide range of dierent bioresorbable RF coils, suitable imaging nerves of dierent sizes and locations. In aim 2, we will experimentally test these coils in normal rats, rats that have undergone an experimental nerve injury, and in human cadaver arms.