Sub-voxel Tissue Characterization with In-Vivo MRI

使用体内 MRI 进行亚体素组织表征

• 批准号: 6929937
• 负责人: MARK D DOES
• 金额: $ 30.2万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6929937
• 关键词: bioimaging /biomedical imaging; body water; brain imaging /visualization /scanning; laboratory rat; magnetic resonance imaging; myelin; nuclear magnetic resonance spectroscopy; relaxation spectrometry; structural biology; technology /technique development

DESCRIPTION (provided by applicant): The overall aims of this project are to develop and implement novel methods for quantitative, in vivo characterization of tissue by magnetic resonance imaging (MRI). The microscopic compartition of water in tissues reflects potentially important structural properties that may be probed by diverse MRI measurements. In particular, water diffusion and nuclear magnetic resonance (NMR) relaxation cannot be described by single components in many tissues. With some limited success, multiple component characterization of these attributes has been proposed and studied in an attempt to extract specific information about the micro-anatomical water compartments from which they are derived. The further development of efficient and effective methods for acquiring and analyzing subvoxel characteristics promises to be useful for assessing structure and pathophysiology in various tissues, particularly nerve and muscle. The studies proposed herein will provide faster, more accurate, and more informative techniques for compartmental studies using MRI. Experimental studies on model tissues will establish comprehensive and quantitative in vivo descriptions of water diffusion, longitudinal relaxation and transverse relaxation, and how they correlate to each other and the physical compartments from which they are derived. These observations will then be used to design novel MRI methods, which are more specific for depicting tissue microstructure in vivo. One example, amongst others, is the aim to develop rapid and easily implemented MRI methods of visualizing and quantifying myelin content in the brain based on detailed compartmental models of relaxation and diffusion in white matter.

描述（由申请人提供）： 该项目的总体目标是开发和实施通过磁共振成像（MRI）对组织进行定量体内表征的新方法。组织中水的微观分配反映了潜在的重要结构特性，可以通过不同的 MRI 测量来探测。特别是，许多组织中的水扩散和核磁共振（NMR）弛豫无法用单一成分来描述。在取得了一些有限的成功后，人们提出并研究了这些属性的多组分表征，试图提取有关它们所源自的微观解剖水室的具体信息。进一步开发用于获取和分析亚体素特征的高效且有效的方法有望有助于评估各种组织（特别是神经和肌肉）的结构和病理生理学。 本文提出的研究将为使用 MRI 的房室研究提供更快、更准确和信息更丰富的技术。对模型组织的实验研究将建立对水扩散、纵向弛豫和横向弛豫的全面和定量的体内描述，以及它们如何相互关联以及它们所源自的物理区室。这些观察结果将用于设计新颖的 MRI 方法，该方法更具体地描述体内组织微观结构。其中一个例子是，目标是开发快速且易于实施的 MRI 方法，基于白质松弛和扩散的详细区室模型来可视化和量化大脑中的髓磷脂含量。