Bone Fracture Risk Assessment Through Bound - and Pore - Water MRI

通过结合水和孔隙水 MRI 评估骨折风险

• 批准号: 8290787
• 负责人: MARK D DOES
• 金额: $ 34.6万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8290787
• 关键词: Accounting; Age; Architecture; Binding; Biological Markers; Biomechanics; Bone Density; Bone Diseases; Bone Marrow; Bone Mineral Contents; Cadaver; Characteristics; Clinical; Collagen; Contralateral; Diagnostic; Diagnostic Imaging; Diaphyses; Disease; Distal; Dual-Energy X-Ray Absorptiometry; Evaluation; Fatty acid glycerol esters; Feedback; Female; Femur; Fourth lumbar vertebra; Fracture; High Pressure Liquid Chromatography; Human; Image; Limb structure; Linear Regressions; Magnetic Resonance Imaging; Marrow; Measurement; Measures; Mechanics; Methods; Motion; Muscle; Neck; Nuclear Magnetic Resonance; Osteoporosis; Pharmacological Treatment; Porosity; Property; Radial; Relative (related person); Relative Risks; Relaxation; Reproducibility; Research; Resistance; Resolution; Risk; Risk Assessment; Roentgen Rays; Sampling; Scanning; Signal Transduction; Simulate; Site; Structure; System; Testing; Time; Translating; Water; X-Ray Computed Tomography; age related; base; bone; bone health; cohort; design; imaging modality; improved; in vivo; indexing; lumbar vertebra bone structure; male; novel; response; soft tissue; tibia; treatment response; volunteer

DESCRIPTION (provided by applicant): The overarching aim of this proposed project is to develop, optimize and quantitatively evaluate magnetic resonance imaging (MRI) methods for evaluating the biomechanical properties of bone. The current standard diagnostic of bone health, dual-energy X-ray absorptiometry (DXA), provides an approximate measure of bone mineral density, but it is a projection method that does not incorporate the full contribution of macro-structure, micro-architecture, collagen, or porosity to fracture resistance. Quantitative computed tomography (qCT) is able to partially circumvent these shortcomings of DXA, but remains limited in that it, and other X-ray based methods, are sensitive only to the mineral content of bone, which accounts for only ~~40% of bone by volume. Recent studies have shown that [1]H nuclear magnetic resonance (NMR) can discern multiple soft- tissue components of bone, including collagen, collagen-bound water, and pore water. Further, in cadaveric cortical bone samples, these NMR measures were found to better predict several mechanical properties related to bone fracture risk than current high resolution qCT. This project seeks to translate these [1]H NMR findings into clinical MRI methods for assessing whole bone fracture risk through three project aims. In Aim 1, [1]H NMR measurements from cortical bone samples will be used to design and test MRI methods for quantitatively measuring bound- and pore-water from bone. In Aim 2, these MRI methods, along with DXA and qCT, will be applied to multiple cadaveric bone sites (including the femoral neck and distal radius). The resulting MRI measures of bound-water, pore-water, and cross-sectional moment of inertia will be correlated with whole bone fracture resistance properties measured from the same sites and a lumbar vertebra. Similar correlations will be made between DXA and qCT measures for comparison. In Aim 3, the MRI methods will be translated to a human MRI system where they will be re-optimized for 3T (c/w 4.7T) and quantitatively evaluated for use at multiple anatomical sites (e.g., distal tibia femoral neck, ...). Ultimately, this project will result in MRI methods with the potential for improved clinical diagnostic evaluation of fracture risk and novel imaging biomarkers for the study bone disease and pharmacological treatment response. PUBLIC HEALTH RELEVANCE: Current methods for diagnostic imaging of bone are incomplete and do not fully predict the increase in fracture risk with age or advancement of disease (such as osteoporosis). Unlike current X-ray based imaging, MRI can probe soft-tissue characteristics of bone, which may be important in fracture resistance. The proposed research aims to develop and evaluate MRI methods that can beDer predict bone fracture risk and provide more specific feedback on bone composition changes in response to therapy.

描述（由申请人提供）：该提出的项目的总体目的是开发，优化和定量评估磁共振成像（MRI）方法，用于评估骨骼的生物力学特性。当前的骨骼健康标准诊断，双能X射线吸收仪（DXA）提供了近似骨矿物质密度的衡量标准，但它是一种投影方法，它不包含宏观结构，微体系结构，胶原蛋白，胶原蛋白或孔隙率对抗性抗性的全部贡献。定量计算机断层扫描（QCT）能够部分规避DXA的这些缺点，但在其中仍然有限，而其他基于X射线的方法仅对骨的矿物质含量敏感，骨骼的矿物质仅占骨头的40％的骨骼。最近的研究表明，[1] H核磁共振（NMR）可以辨别骨的多个软组织成分，包括胶原蛋白，结合胶原蛋白的水和孔隙水。此外，在尸体皮质骨样品中，发现这些NMR测量可以更好地预测与骨断裂风险相关的几种机械性能，而不是当前的高分辨率QCT。该项目旨在将这些[1] H NMR发现转化为临床MRI方法，以通过三个项目的目标评估整个骨折风险。在AIM 1中，[1]来自皮质骨样品的H NMR测量将用于设计和测试MRI方法，以定量测量骨骼的边界和孔隙水。在AIM 2中，这些MRI方法以及DXA和QCT将应用于多个尸体骨位点（包括股骨颈和远端半径）。所得的结合水，孔隙水和横截面的MRI度量与从相同部位和腰椎椎骨测量的全骨断裂性能相关。 DXA和QCT度量之间将进行类似的相关性，以进行比较。在AIM 3中，MRI方法将被转化为人类MRI系统，在该系统中将重新优化为3T（C/W 4.7T），并进行定量评估以在多个解剖部位（例如，股骨股骨远端颈部颈部，...）。最终，该项目将导致MRI方法，并有可能改善研究骨病和药理治疗反应的骨折风险和新型成像生物标志物的临床诊断评估。 公共卫生相关性：当前骨骼诊断成像的方法不完整，并且不能完全预测随着年龄或疾病发展（例如骨质疏松症）的破裂风险增加。与当前基于X射线的成像不同，MRI可以探测骨骼的软组织特征，这在断裂耐药性中​​可能很重要。拟议的研究旨在开发和评估MRI方法，以预测骨折风险，并为响应治疗的骨骼组成变化提供更具体的反馈。