Bone Fracture Risk Assessment Through Bound - and Pore - Water MRI
通过结合水和孔隙水 MRI 评估骨折风险
基本信息
- 批准号:8290787
- 负责人:
- 金额:$ 34.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-03-15 至 2016-02-29
- 项目状态:已结题
- 来源:
- 关键词:AccountingAgeArchitectureBindingBiological MarkersBiomechanicsBone DensityBone DiseasesBone MarrowBone Mineral ContentsCadaverCharacteristicsClinicalCollagenContralateralDiagnosticDiagnostic ImagingDiaphysesDiseaseDistalDual-Energy X-Ray AbsorptiometryEvaluationFatty acid glycerol estersFeedbackFemaleFemurFourth lumbar vertebraFractureHigh Pressure Liquid ChromatographyHumanImageLimb structureLinear RegressionsMagnetic Resonance ImagingMarrowMeasurementMeasuresMechanicsMethodsMotionMuscleNeckNuclear Magnetic ResonanceOsteoporosisPharmacological TreatmentPorosityPropertyRadialRelative (related person)Relative RisksRelaxationReproducibilityResearchResistanceResolutionRiskRisk AssessmentRoentgen RaysSamplingScanningSignal TransductionSimulateSiteStructureSystemTestingTimeTranslatingWaterX-Ray Computed Tomographyage relatedbasebonebone healthcohortdesignimaging modalityimprovedin vivoindexinglumbar vertebra bone structuremalenovelresponsesoft tissuetibiatreatment responsevolunteer
项目摘要
DESCRIPTION (provided by applicant): The overarching aim of this proposed project is to develop, optimize and quantitatively evaluate magnetic resonance imaging (MRI) methods for evaluating the biomechanical properties of bone. The current standard diagnostic of bone health, dual-energy X-ray absorptiometry (DXA), provides an approximate measure of bone mineral density, but it is a projection method that does not incorporate the full contribution of macro-structure, micro-architecture, collagen, or porosity to fracture resistance. Quantitative computed tomography (qCT) is able to partially circumvent these shortcomings of DXA, but remains limited in that it, and other X-ray based methods, are sensitive only to the mineral content of bone, which accounts for only ~~40% of bone by volume. Recent studies have shown that [1]H nuclear magnetic resonance (NMR) can discern multiple soft- tissue components of bone, including collagen, collagen-bound water, and pore water. Further, in cadaveric cortical bone samples, these NMR measures were found to better predict several mechanical properties related to bone fracture risk than current high resolution qCT. This project seeks to translate these [1]H NMR findings into clinical MRI methods for assessing whole bone fracture risk through three project aims. In Aim 1, [1]H NMR measurements from cortical bone samples will be used to design and test MRI methods for quantitatively measuring bound- and pore-water from bone. In Aim 2, these MRI methods, along with DXA and qCT, will be applied to multiple cadaveric bone sites (including the femoral neck and distal radius). The resulting MRI measures of bound-water, pore-water, and cross-sectional moment of inertia will be correlated with whole bone fracture resistance properties measured from the same sites and a lumbar vertebra. Similar correlations will be made between DXA and qCT measures for comparison. In Aim 3, the MRI methods will be translated to a human MRI system where they will be re-optimized for 3T (c/w 4.7T) and quantitatively evaluated for use at multiple anatomical sites (e.g., distal tibia femoral neck, ...). Ultimately, this project will result in MRI methods with the potential for improved clinical diagnostic evaluation of fracture risk and novel imaging biomarkers for the study bone disease and pharmacological treatment response.
PUBLIC HEALTH RELEVANCE: Current methods for diagnostic imaging of bone are incomplete and do not fully predict the increase in fracture risk with age or advancement of disease (such as osteoporosis). Unlike current X-ray based imaging, MRI can probe soft-tissue characteristics of bone, which may be important in fracture resistance. The proposed research aims to develop and evaluate MRI methods that can beDer predict bone fracture risk and provide more specific feedback on bone composition changes in response to therapy.
描述(由申请人提供):本项目的总体目标是开发,优化和定量评估用于评估骨骼生物力学特性的磁共振成像(MRI)方法。目前诊断骨骼健康的标准方法是双能x射线吸收仪(DXA),它提供了骨密度的近似测量,但它是一种投影方法,不能将宏观结构、微观结构、胶原蛋白或孔隙度对抗骨折性的全部贡献纳入其中。定量计算机断层扫描(qCT)能够部分规避DXA的这些缺点,但仍有局限性,因为它和其他基于x射线的方法只对骨骼的矿物质含量敏感,而骨骼的矿物质含量仅占骨骼体积的~~40%。最近的研究表明,bbbbh核磁共振(NMR)可以识别骨骼的多种软组织成分,包括胶原蛋白、胶原结合水和孔隙水。此外,在尸体皮质骨样本中,这些核磁共振测量比目前的高分辨率qCT更能预测与骨折风险相关的几种力学特性。本项目旨在通过三个项目目标将这些b[1]H核磁共振结果转化为评估全骨骨折风险的临床MRI方法。在目标1中,来自皮质骨样本的b[1]H NMR测量将用于设计和测试定量测量骨结合水和孔隙水的MRI方法。在Aim 2中,这些MRI方法,以及DXA和qCT,将应用于多个尸体骨部位(包括股骨颈和桡骨远端)。所得的束缚水、孔隙水和横截面惯性矩的MRI测量结果将与从同一部位和腰椎测量的全骨骨折抵抗特性相关。类似的相关性将在DXA和qCT测量之间进行比较。在Aim 3中,MRI方法将被转化为人体MRI系统,在那里它们将被重新优化为3T (c/w 4.7T),并定量评估用于多个解剖部位(例如,胫骨远端股骨颈等)。最终,该项目将使MRI方法具有改善骨折风险的临床诊断评估的潜力,并为研究骨病和药物治疗反应提供新的成像生物标志物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MARK D DOES其他文献
MARK D DOES的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MARK D DOES', 18)}}的其他基金
Bioresorbable RF Coils For Post-Surgical Monitoring by MRI
用于术后 MRI 监测的生物可吸收射频线圈
- 批准号:
9896142 - 财政年份:2020
- 资助金额:
$ 34.6万 - 项目类别:
MRI Toolbox for Rodent Brain Microstructure Imaging
用于啮齿动物脑微结构成像的 MRI 工具箱
- 批准号:
9188074 - 财政年份:2015
- 资助金额:
$ 34.6万 - 项目类别:
MRI Toolbox for Rodent Brain Microstructure Imaging
用于啮齿动物脑微结构成像的 MRI 工具箱
- 批准号:
9026974 - 财政年份:2015
- 资助金额:
$ 34.6万 - 项目类别:
Bone Fracture Risk Assessment Through Bound - and Pore - Water MRI
通过结合水和孔隙水 MRI 评估骨折风险
- 批准号:
8628117 - 财政年份:2012
- 资助金额:
$ 34.6万 - 项目类别:
Bone Fracture Risk Assessment Through Bound - and Pore - Water MRI
通过结合水和孔隙水 MRI 评估骨折风险
- 批准号:
8811946 - 财政年份:2012
- 资助金额:
$ 34.6万 - 项目类别:
Bone Fracture Risk Assessment Through Bound - and Pore - Water MRI
通过结合水和孔隙水 MRI 评估骨折风险
- 批准号:
8440289 - 财政年份:2012
- 资助金额:
$ 34.6万 - 项目类别:
Sub-voxel Tissue Characterization with In-Vivo MRI
使用体内 MRI 进行亚体素组织表征
- 批准号:
6803479 - 财政年份:2003
- 资助金额:
$ 34.6万 - 项目类别:
Sub-voxel Tissue Characterization with In-Vivo MRI
使用体内 MRI 进行亚体素组织表征
- 批准号:
6929937 - 财政年份:2003
- 资助金额:
$ 34.6万 - 项目类别:
Sub-Voxel Tissue Characterization With In-Vivo MRI
使用体内 MRI 进行亚体素组织表征
- 批准号:
8237221 - 财政年份:2003
- 资助金额:
$ 34.6万 - 项目类别:
Sub-Voxel Tissue Characterization With In-Vivo MRI
使用体内 MRI 进行亚体素组织表征
- 批准号:
8333253 - 财政年份:2003
- 资助金额:
$ 34.6万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Deconstructing and Modeling the Single Cell Architecture of the Age-Related Macular Degeneration Retina and RPE/Choroid
年龄相关性黄斑变性视网膜和 RPE/脉络膜的单细胞结构的解构和建模
- 批准号:
10450171 - 财政年份:2020
- 资助金额:
$ 34.6万 - 项目类别:
Deconstructing and Modeling the Single Cell Architecture of the Age-Related Macular Degeneration Retina and RPE/Choroid
年龄相关性黄斑变性视网膜和 RPE/脉络膜的单细胞结构的解构和建模
- 批准号:
10674702 - 财政年份:2020
- 资助金额:
$ 34.6万 - 项目类别:
Deconstructing and Modeling the Single Cell Architecture of the Age-Related Macular Degeneration Retina and RPE/Choroid
年龄相关性黄斑变性视网膜和 RPE/脉络膜的单细胞结构的解构和建模
- 批准号:
10242936 - 财政年份:2020
- 资助金额:
$ 34.6万 - 项目类别:
Deconstructing and Modeling the Single Cell Architecture of the Age-Related Macular Degeneration Retina and RPE/Choroid
年龄相关性黄斑变性视网膜和 RPE/脉络膜的单细胞结构的解构和建模
- 批准号:
10058444 - 财政年份:2020
- 资助金额:
$ 34.6万 - 项目类别:
The evolution of House Architecture in the Portuguese Estremadura from Copper- to Iron Age. The evolution of Architecture, Function and Social Significance
葡萄牙埃斯特雷马杜拉从铜器时代到铁器时代房屋建筑的演变。
- 批准号:
335673224 - 财政年份:2017
- 资助金额:
$ 34.6万 - 项目类别:
Research Grants
Elucidating the Genetic Architecture of Age-Dependent Neurodegenerative Diseases
阐明年龄依赖性神经退行性疾病的遗传结构
- 批准号:
376840 - 财政年份:2017
- 资助金额:
$ 34.6万 - 项目类别:
Fellowship Programs
Architecture and Society in an Age of Reform
改革时代的建筑与社会
- 批准号:
AH/P00993X/1 - 财政年份:2017
- 资助金额:
$ 34.6万 - 项目类别:
Research Grant
Mechanistic understanding of age-dependent genetic architecture
对年龄依赖性遗传结构的机制理解
- 批准号:
8985319 - 财政年份:2015
- 资助金额:
$ 34.6万 - 项目类别:
Mechanistic understanding of age-dependent genetic architecture
对年龄依赖性遗传结构的机制理解
- 批准号:
9753013 - 财政年份:2015
- 资助金额:
$ 34.6万 - 项目类别:
Mechanistic understanding of age-dependent genetic architecture
对年龄依赖性遗传结构的机制理解
- 批准号:
9321149 - 财政年份:2015
- 资助金额:
$ 34.6万 - 项目类别: