Sub-Voxel Tissue Characterization With In-Vivo MRI

使用体内 MRI 进行亚体素组织表征

• 批准号: 8237221
• 负责人: MARK D DOES
• 金额: $ 34.6万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8237221
• 关键词: Address; Anatomy; Autistic Disorder; Biological Markers; Caliber; Cerebrum; Characteristics; Chemicals; Clinical; Complex; Computer Simulation; Data; Development; Diagnostic; Diagnostic Imaging; Diffusion; Disease; Duchenne muscular dystrophy; Environment; Evaluation; Exhibits; Fibrosis; Foundations; Funding; Gold; Histology; Image; Imagery; Inflammation; Injury; Magnetic Resonance Imaging; Measures; Methods; Modeling; Muscle; Muscular Dystrophies; Myelin; Neuraxis; Nuclear Magnetic Resonance; Paper; Peripheral; Physiologic pulse; Preparation; Protocols documentation; Protons; Rattus; Relaxation; Reperfusion Injury; Research; Research Personnel; Schizophrenia; Signal Transduction; Skeletal Muscle; Slice; Specificity; Spinal; Testing; Thick; Tissue Model; Tissues; Translating; Variant; Water; Work; base; clinically relevant; computerized tools; imaging modality; in vivo; injured; method development; model development; mouse model; novel; prognostic; programs; relating to nervous system; research study; simulation; soft tissue; water diffusion; white matter

DESCRIPTION (provided by applicant): Magnetic resonance imaging (MRI) is a uniquely informative soft tissue imaging modality with contrast that is sensitive to a myriad of physical, chemical, and functional characteristics of tissue but often lacks specificity. On the spatial scale relevant to water proton (1H) nuclear magnetic resonance (NMR), tissues are heterogeneous and, consequently, exhibit an NMR signal that is the complex summation of spatially varying characteristics. Most MRI protocols provide contrast between tissues that can be resolved spatially, but yield little or no quantitative information about the variation in NMR signal that exists on a smaller scale, that is, the sub-voxel scale. This quantitative sub-voxel information is alluring because it provides specificity to tissue micro-anatomy. Development of quantitative sub-voxel MRI tissue characterization requires coordinated advancement on two fronts: 1) quantitative models that relate relevant micro-anatomical characteristics to 1H NMR signal characteristics, and 2) practical and effective quantitative MRI methods that can translate these the use of sub-voxel tissue models to widespread utility for researchers and clinicians. The proposed studies address both modeling and method development with the aim to develop practical and quantitative imaging biomarkers for micro-anatomical characteristics of white matter and skeletal muscle, including 1) myelin volume fraction and myelin thickness in normal, developing, and abnormally developing white matter, and 2) myofiber volume fraction and size, in the presence of inflammation and fibrosis. Such biomarkers have the potential to impact research and clinical diagnostics by providing quantitative and specific measures to track changes in disorders associated with abnormal white matter development, such as Schizophrenia and Autism, as well muscle injuries and diseases such as Muscular Dystrophy. PUBLIC HEALTH RELEVANCE: MRI is a widespread diagnostic imaging modality capable of relatively non-invasive visualization of soft tissue. The contrast in MRI results from many complex interactions of water molecules in the body with each other and the physical and chemical characteristics of their local environments. This research program aims to better relate MRI contrast to specific micro-anatomical characteristics in neural tissue and skeletal muscle. This work has broad potential impact the diagnostic and prognostic capabilities of MRI for a wide array of diseases and injuries.

描述(申请人提供)：磁共振成像(MRI)是一种独特的信息丰富的软组织成像方式，具有对比度，对组织的各种物理、化学和功能特征敏感，但通常缺乏特异性。在与水质子(1H)核磁共振(1H)相关的空间尺度上，组织是异质的，因此呈现出核磁共振信号，这是空间变化特征的复杂总和。大多数MRI协议提供了可在空间上分辨的组织之间的对比度，但很少或根本没有关于存在于较小尺度上的核磁共振信号变化的定量信息，即亚体素尺度。这种定量的亚体素信息是诱人的，因为它提供了组织显微解剖的特异性。亚体素MRI定量组织定征的发展需要在两个方面协调发展：1)将相关显微解剖特征与1H核磁共振信号特征联系起来的定量模型；2)实用有效的定量MRI方法，将亚体素组织模型的使用转化为研究人员和临床医生的广泛实用。建议的研究包括建模和方法开发，目的是开发实用和定量的白质和骨骼肌显微解剖特征的成像生物标志物，包括1)正常、发育和异常发育的白质中的髓鞘体积分数和髓鞘厚度，以及2)炎症和纤维化存在时的肌纤维体积分数和大小。这些生物标志物有可能影响研究和临床诊断，因为它们提供了定量和具体的措施，以跟踪与白质发育异常相关的疾病的变化，如精神分裂症和自闭症，以及肌肉损伤和肌营养不良症等疾病。 公共卫生相关性：MRI是一种广泛使用的诊断成像方式，能够相对非侵入性地显示软组织。磁共振成像中的对比度是由于体内水分子之间的许多复杂相互作用及其局部环境的物理和化学特征造成的。这项研究计划旨在更好地将MRI对比度与神经组织和骨骼肌的特定微观解剖特征联系起来。这项工作对MRI对一系列疾病和损伤的诊断和预后能力具有广泛的潜在影响。