Personal Dosimeter for OPs Using Nano-structured Surface

使用纳米结构表面的 OP 个人剂量计

• 批准号: 6791842
• 负责人: Barbara A. Israel
• 金额: $ 92.93万
• 依托单位: PLATYPUS TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6791842
• 关键词: biomedical equipment development; dosage; environmental exposure; liquid crystal; nanotechnology; organophosphorus insecticide; patient monitoring device; pesticide biological effect; portable biomedical equipment

DESCRIPTION (provided by applicant): The long-term goal of this project is to develop a passive monitor for measurement of cumulative exposure to organophosphate (OP) pesticides. This monitor is based on the innovative exploitation of the anchoring of liquid crystals to a surface functionalized with metal ions. In Phase 1, we demonstrated the ability to select combinations of metals that would selectively bind OPs and to design multi-arrays of metals to identify individual OPs. We also demonstrated the use of this new technology to measure cumulative exposure to ppb concentrations of commercial formulations of OP pesticides over a three-week period. The surfaces we created were not affected by humidity and exhibited stability. These data strongly support the feasibility of Platypus TM technology as the basis of small, inexpensive, rugged passive monitors suitable for measuring cumulative pesticide exposure in children and adults. In Phase 2, we will examine the effects of potential interfering compounds, we will calibrate our prototype monitors against standard sampling methods under laboratory and field conditions and we will optimize choice of materials, housing, and read out methods to incorporate in the design of a field prototype monitor. This prototype will be tested under field conditions to determine precision and accuracy.

描述（由申请人提供）：该项目的长期目标是开发一个被动监视器，以测量有机磷酸盐（OP）农药的累积暴露。该监视器基于将液晶锚定在用金属离子功能化的表面的创新开发。在阶段1中，我们证明了选择将有选择地绑定OPS并设计多金属的金属组合的能力，以识别单个OPS。我们还证明了使用这项新技术在三周的时间内测量OP农药的商业配方浓度的累积暴露。我们创建的表面不受湿度的影响，并且表现出稳定性。这些数据强烈支持鸭嘴兽TM技术的可行性，这是小型，廉价，坚固的被动监视器，适合于测量儿童和成人的累积农药暴露。在第2阶段，我们将检查潜在干扰化合物的影响，我们将在实验室和现场条件下针对标准采样方法校准原型监测器，我们将优化材料的选择，外壳和读取方法，以将方法纳入田间原型监测器的设计中。该原型将在现场条件下进行测试，以确定精度和准确性。