Personal Dosimeter for OPs Using Nano-structured Surface

使用纳米结构表面的 OP 个人剂量计

• 批准号: 6791842
• 负责人: Barbara A. Israel
• 金额: $ 92.93万
• 依托单位: PLATYPUS TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6791842
• 关键词: biomedical equipment development; dosage; environmental exposure; liquid crystal; nanotechnology; organophosphorus insecticide; patient monitoring device; pesticide biological effect; portable biomedical equipment

DESCRIPTION (provided by applicant): The long-term goal of this project is to develop a passive monitor for measurement of cumulative exposure to organophosphate (OP) pesticides. This monitor is based on the innovative exploitation of the anchoring of liquid crystals to a surface functionalized with metal ions. In Phase 1, we demonstrated the ability to select combinations of metals that would selectively bind OPs and to design multi-arrays of metals to identify individual OPs. We also demonstrated the use of this new technology to measure cumulative exposure to ppb concentrations of commercial formulations of OP pesticides over a three-week period. The surfaces we created were not affected by humidity and exhibited stability. These data strongly support the feasibility of Platypus TM technology as the basis of small, inexpensive, rugged passive monitors suitable for measuring cumulative pesticide exposure in children and adults. In Phase 2, we will examine the effects of potential interfering compounds, we will calibrate our prototype monitors against standard sampling methods under laboratory and field conditions and we will optimize choice of materials, housing, and read out methods to incorporate in the design of a field prototype monitor. This prototype will be tested under field conditions to determine precision and accuracy.

描述（由申请人提供）：本项目的长期目标是开发一种被动监测仪，用于测量有机磷农药（OP）的累积暴露。该监测器是基于创新性的开发锚定的液晶与金属离子功能化的表面。在第一阶段，我们展示了选择金属组合的能力，这些金属组合将选择性地结合OP，并设计多金属阵列以识别单个OP。我们还展示了使用这种新技术来测量三周内OP农药商业制剂ppb浓度的累积暴露。我们创建的表面不受湿度的影响，并表现出稳定性。这些数据有力地支持了Platypus TM技术作为小型、廉价、坚固耐用的被动监测器的基础的可行性，该监测器适用于测量儿童和成人的累积农药暴露。在第二阶段，我们将检查潜在干扰化合物的影响，我们将根据实验室和现场条件下的标准采样方法校准我们的原型监测器，我们将优化材料，外壳的选择，并将读出方法纳入现场原型监测器的设计中。该原型将在现场条件下进行测试，以确定精度和准确性。