Multiplexed Personal Monitoring of Airborne Toxins

空气中毒素的多重个人监测

• 批准号: 7155427
• 负责人: Barbara A. Israel
• 金额: $ 23.02万
• 依托单位: PLATYPUS TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7155427
• 关键词: air pollution; air sampling /monitoring; biohazard detection; environmental toxicology; industrial waste; monitoring device; nanotechnology; pesticides; technology /technique development

DESCRIPTION (provided by applicant):Project Summary/Abstract: Quantitative monitoring of personal exposure to environmental toxins is currently limited by expense, inconvenience and lack of appropriate technology, yet such monitoring is needed for investigation of health effects caused by low dose, chronic exposure to compounds such as pesticides or industrial toxins. We have previously demonstrated that low concentrations of a semi-volatile organophosphate pesticide can be detected from a vapor phase by utilizing chemically functionalized, nanostructured surfaces and liquid crystals (PlatypusTM technology). What is needed, however, is a monitor that simultaneously measures exposure to multiple compounds. In this proposal, we will demonstrate the feasibility of developing Platypus TM technology for the quantitative and simultaneous detection of 2 different classes of semi-volatile pesticides (carbamates and organophosphates) and for the discrimination of specific compounds within each class of pesticide. The technology developed in this project can be adapted for detection of other industrial or environmental contaminants that are semi-volatile, and thus it has the potential to serve as the basis for a broadly useful, convenient and inexpensive class of passive monitors for multi-compound personal exposure assessment and environmental monitoring. Project Narrative: In this proposal, we are developing a small, inexpensive wearable device which will provide a measurement of an individual's exposure to multiple chemicals present in his or her environment over a period of a day to a few weeks. This data is essential for associating exposure to specific compounds with adverse affects on public health.

描述（由申请人提供）：项目摘要/摘要：当前对个人接触环境毒素接触的定量监测受费用，不便和缺乏适当的技术的限制，但是需要进行这种监测以调查由低剂量，长期暴露于农药或工业毒素等化合物引起的健康影响。我们先前已经证明，可以通过使用化学功能化的纳米结构表面和液晶（Platypustm Technology）从蒸气相中检测到低浓度的半挥发性有机磷酸盐农药。但是，需要的是一个同时测量多种化合物的监视器。在此提案中，我们将证明开发鸭嘴兽TM技术的可行性，用于定量和同时检测2种不同类别的半挥发性农药（氨基甲酸酯和有机磷酸盐），以及在每类农药中歧视特定化合物的可行性。该项目中开发的技术可以适应半挥发性的其他工业或环境污染物，因此它有可能作为多种多样的个人暴露评估和环境监测的广泛有用，方便且廉价的被动监测器的基础。项目叙述：在此提案中，我们正在开发一种小型，廉价的可穿戴设备，该设备将在一天到几周的一段时间内对个人暴露于其环境中存在的多种化学物质的暴露。该数据对于将暴露于对公共卫生的不利影响的特定化合物的接触至关重要。