Biophotonic Detection of WNV ABS. for Multiple Species

描述（由申请方提供）：动物流行病调查显示 在多个物种中检测抗体的挑战。ELISA方法 通常用于筛选大量样本的抗体，需要 种特异性二抗。在最近爆发的西尼罗河病毒中 病毒在纽约市，至少18种鸟类，以及马和 人类已经感染了这种病毒。鸭嘴兽的技术是基于 液晶对纳米尺度表面变化的灵敏度 金薄膜的形貌。任何物种的抗体与 显示在表面上的特定受体在几秒钟内被报告， 可见光通过液晶单元的转换。这个平台 该技术快速、灵敏（可检测1000个分子），适用于 低技术环境，适应自动化。它会找到 在研究、临床诊断、流行病学、药物 发现和许多其他领域。我们将开发一种检测西尼罗河病毒的方法 任何物种的病毒抗体。 拟定商业应用： Platypus技术是一种基础广泛的平台技术， 在检测分子相互作用至关重要的所有领域。人们越来越 快速病毒诊断市场。我们的技术可以使诊断更接近 护理点。检测来自多个物种的抗体的能力将具有巨大价值 到流行病学研究。

DESCRIPTION (provided by applicant):The investigation of an epizootic presents the challenge of detecting antibodies in multiple species. ELISA, the method commonly used for screening large numbers of samples for antibodies, requires species-specific secondary antibodies. In the recent outbreak of West Nile virus in New York City, at least 18 species of birds, as well as horses and humans have been infected with the virus. Platypus technology is based on the exquisite sensitivity of liquid crystals to nanometer scale changes in surface topography of thin films of gold. The binding of antibodies from any species to specific receptors displayed on the surface is reported within seconds by the transduction of visible light through a liquid crystal cell. This platform technology is rapid, sensitive (1000 molecules can be detected), suitable for low technology environments and is adaptable to automation. It will find numerous applications in research, clinical diagnostics, epidemiology, drug discovery and many other areas. We will develop an assay to detect West Nile virus antibodies from any species based on this technology. PROPOSED COMMERCIAL APPLICATION: Platypus technology is a broad-based platform technology that will have application in all fields where the detection of molecular interactions is critical. There is a growing market for rapid viral diagnostics. Our technology can bring diagnosis closer to the point of care. The ability to detect antibodies from multiple species will be of great value to epidemiologic studies.