Electro-Active Physiological Interface

电活性生理接口

• 批准号: 6735239
• 负责人: PHAN LUU
• 金额: $ 11.46万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-15 至 2004-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6735239
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial interface interaction; biosensor device; biotechnology; clinical research; electroencephalography; electrophysiology; gel; human subject; surface property

DESCRIPTION (provided by applicant): Electrophysiologic recording provides inexpensive and non-invasive monitoring of both normal and pathological human brain function. With a saline-sponge technology, a dense array of 64, 128, or 256 electrodes can be applied in a few minutes, allowing electroencephalographic (EEG) recording in emergency and intensive care settings. However, EEG evaluations in demanding clinical settings often require long-term monitoring, and the current sponge-saline electrode technology provides usable EEG for only 2-3 hours before re-hydration is required. Long-term recordings can be accomplished by the use of conventional electrode pastes or glues, but the discomfort and preparation time become major impediments in many medical settings for which brain monitoring may be useful. This Phase I project proposes the creation of a novel Phase-Reversible Electro-Physiological Sensor (PREPS) that allows long-term recording to become as fast and comfortable as our sponge-saline technology. The PREPS is a hydrogel whose viscosity is changed by a stimulus (such as electrical current or temperature). Based on our promising pilot data, this Phase I project will perform systematic feasibility studies to optimize the viscosity of the hydrogel, determine practical ranges for phase-reversible operation with electrical current and temperature manipulations, and achieve both skin bonding and skin hydration to produce high quality extended EEG monitoring with the PREPS technology.

描述（由申请人提供）：电生理记录提供了对正常和病理人脑功能的廉价且非侵入性的监测。借助盐水海绵技术，可以在几分钟内应用 64、128 或 256 个电极的密集阵列，从而可以在紧急情况和重症监护环境中进行脑电图 (EEG) 记录。然而，在苛刻的临床环境中进行脑电图评估通常需要长期监测，而目前的海绵盐水电极技术在需要补水之前仅提供可用的脑电图 2-3 小时。长期记录可以通过使用传统的电极糊或胶水来完成，但不适和准备时间成为许多医疗环境中的主要障碍，而脑监测可能对这些环境有用。该第一阶段项目建议创建一种新型相可逆电生理传感器（PREPS），使长期记录变得像我们的海绵盐水技术一样快速和舒适。 PREPS 是一种水凝胶，其粘度会因刺激（例如电流或温度）而改变。基于我们有希望的试点数据，该第一阶段项目将进行系统的可行性研究，以优化水凝胶的粘度，确定 通过电流和温度操纵进行相可逆操作的实用范围，并实现皮肤粘合和皮肤水合作用，以利用 PREPS 技术产生高质量的扩展脑电图监测。