Electro-Active Physiological Interface

电活性生理接口

• 批准号: 6735239
• 负责人: PHAN LUU
• 金额: $ 11.46万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-15 至 2004-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6735239
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial interface interaction; biosensor device; biotechnology; clinical research; electroencephalography; electrophysiology; gel; human subject; surface property

DESCRIPTION (provided by applicant): Electrophysiologic recording provides inexpensive and non-invasive monitoring of both normal and pathological human brain function. With a saline-sponge technology, a dense array of 64, 128, or 256 electrodes can be applied in a few minutes, allowing electroencephalographic (EEG) recording in emergency and intensive care settings. However, EEG evaluations in demanding clinical settings often require long-term monitoring, and the current sponge-saline electrode technology provides usable EEG for only 2-3 hours before re-hydration is required. Long-term recordings can be accomplished by the use of conventional electrode pastes or glues, but the discomfort and preparation time become major impediments in many medical settings for which brain monitoring may be useful. This Phase I project proposes the creation of a novel Phase-Reversible Electro-Physiological Sensor (PREPS) that allows long-term recording to become as fast and comfortable as our sponge-saline technology. The PREPS is a hydrogel whose viscosity is changed by a stimulus (such as electrical current or temperature). Based on our promising pilot data, this Phase I project will perform systematic feasibility studies to optimize the viscosity of the hydrogel, determine practical ranges for phase-reversible operation with electrical current and temperature manipulations, and achieve both skin bonding and skin hydration to produce high quality extended EEG monitoring with the PREPS technology.

描述（由申请人提供）：电生理记录提供了对正常和病理人脑功能的廉价且无创的监测。使用盐水海绵技术，可以在几分钟内使用64、128或256个电极的密集阵列，从而可以在紧急和重症监护设置中进行脑电图（EEG）记录。但是，在苛刻的临床环境中进行的脑电图评估通常需要长期监测，并且当前的海绵 - 盐电极技术仅在需要重新缩水之前仅2-3小时提供可用的脑电图。长期记录可以通过使用常规电极糊或胶水来完成，但是在许多医疗环境中，不适和准备时间成为可能有用的许多医疗环境中的主要障碍。该阶段I项目提出了一种新型相可逆的电生理传感器（PREP）的创建，该传感器（PREP）允许长期记录变得像我们的海绵岩石技术一样快，舒适。预备是一种水凝胶，其粘度通过刺激（例如电流或温度）改变。根据我们有前途的飞行员数据，该阶段I项目将执行系统的可行性研究以优化水凝胶的粘度，确定 使用电流和温度操作的相位可逆操作的实用范围，并同时实现皮肤粘合和皮肤水合，从而通过Preps技术产生高质量的EEG监测。