Electro-Active Physiological Interface

电活性生理接口

• 批准号: 6935649
• 负责人: PHAN LUU
• 金额: $ 34.83万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6935649
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial interface interaction; biosensor device; biotechnology; clinical research; electroencephalography; electrophysiology; gel; human subject; surface property

DESCRIPTION (provided by applicant): Electrophysiologic recording provides inexpensive and non-invasive monitoring of both normal and pathological human brain function. With a saline-sponge technology, a dense array of 64,128, or 256 electrodes can be applied in a few minutes, allowing electroencephalographic (EEG) recording in emergency and intensive care settings. However, EEG evaluations in demanding clinical settings often require long-term monitoring, and the current sponge-saline electrode technology provides usable EEG for only 2-3 hours before re-hydration is required. Long-term recordings can be accomplished by the use of conventional electrode pastes or glues, but the discomfort and preparation time become major impediments in many medical settings for which brain monitoring may be useful. This Phase II proposal follows on the successful completion of the Phase I project, which demonstrated the ability to build an EEG electrolyte based on stimulus-responsive hydrogel technology. The Phase II project proposes the refinement of this novel Phase- Reversible Electro-Physiological Sensor (PREPS) electrolyte technology that will permit long-term recording with dense electrode arrays to be fast and comfortable. PREPS technology allows for the manipulations of the electrolyte with either electric current or temperature to achieve both skin bonding and skin hydration to produce high quality extended EEG monitoring. Based on the Phase I results, this Phase II project will perform systematic refinement studies to optimize the PREPS technology for dermal EEG applications and develop and test protocols for PREPS in clinical settings.

描述（由申请人提供）：电生理记录提供了对正常和病理人脑功能的廉价且无创的监测。使用盐水海绵技术，可以在几分钟内使用64,128的密集阵列，或256个电极，从而在紧急和重症监护设置中进行脑电图（EEG）记录。但是，在苛刻的临床环境中进行的脑电图评估通常需要长期监测，并且当前的海绵 - 盐电极技术仅在需要重新缩水之前仅2-3小时提供可用的脑电图。长期记录可以通过使用常规电极糊或胶水来完成，但是在许多医疗环境中，不适和准备时间成为可能有用的许多医疗环境中的主要障碍。该第二阶段的建议遵循了I期项目的成功完成，该项目证明了基于刺激反应性水凝胶技术构建脑电图电解质的能力。第二阶段项目提出了这种新型相可逆的电生理传感器（PREPS）电解质技术的完善，该技术将允许使用密集电极阵列的长期记录快速舒适。 Preps技术允许用电流或温度对电解质进行操纵，以实现皮肤粘合和皮肤水合，以产生高质量的扩展脑电图监测。基于I阶段的结果，该II期项目将进行系统的完善研究，以优化针对皮肤EEG应用的PREPS技术，并为临床环境中的PREPS开发和测试协议。