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Electro-Active Physiological Interface

电活性生理接口

基本信息

批准号：
7089123
负责人：
PHAN LUU
金额：
$ 39.34万
依托单位：
ELECTRICAL GEODESICS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-03-01 至 2008-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Electrophysiologic recording provides inexpensive and non-invasive monitoring of both normal and pathological human brain function. With a saline-sponge technology, a dense array of 64,128, or 256 electrodes can be applied in a few minutes, allowing electroencephalographic (EEG) recording in emergency and intensive care settings. However, EEG evaluations in demanding clinical settings often require long-term monitoring, and the current sponge-saline electrode technology provides usable EEG for only 2-3 hours before re-hydration is required. Long-term recordings can be accomplished by the use of conventional electrode pastes or glues, but the discomfort and preparation time become major impediments in many medical settings for which brain monitoring may be useful. This Phase II proposal follows on the successful completion of the Phase I project, which demonstrated the ability to build an EEG electrolyte based on stimulus-responsive hydrogel technology. The Phase II project proposes the refinement of this novel Phase- Reversible Electro-Physiological Sensor (PREPS) electrolyte technology that will permit long-term recording with dense electrode arrays to be fast and comfortable. PREPS technology allows for the manipulations of the electrolyte with either electric current or temperature to achieve both skin bonding and skin hydration to produce high quality extended EEG monitoring. Based on the Phase I results, this Phase II project will perform systematic refinement studies to optimize the PREPS technology for dermal EEG applications and develop and test protocols for PREPS in clinical settings.

描述(由申请人提供)：电生理记录提供了对正常和病理人脑功能的廉价和非侵入性监测。使用盐水海绵技术，可以在几分钟内应用64、128或256个电极的密集阵列，从而在急救和重症监护环境中记录脑电(EEG)。然而，在要求苛刻的临床环境中进行脑电评估通常需要长期监测，目前的海绵-盐水电极技术在需要重新水化之前只提供2-3小时的可用脑电。长期记录可以通过使用传统的电极糊或胶水来完成，但在许多大脑监测可能有用的医疗环境中，不适和准备时间成为主要障碍。这项第二阶段提案是在第一阶段项目成功完成之后提出的，该项目展示了基于刺激响应水凝胶技术构建脑电电解液的能力。第二阶段项目建议对这种新型的可逆电生理传感器(PREPS)电解液技术进行改进，使高密度电极阵列的长期记录变得快速和舒适。PREPS技术允许在电流或温度下操纵电解液，以实现皮肤粘合和皮肤水合，从而产生高质量的扩展脑电监测。基于第一阶段的结果，这个第二阶段的项目将进行系统的改进研究，以优化用于真皮EEG应用的PREPS技术，并开发和测试临床环境中的PREPS方案。