STROKE MONITORING WITH DENSE-ARRAY EEG

使用密集阵列脑电图进行中风监测

• 批准号: 6152993
• 负责人: PHAN LUU
• 金额: $ 11.89万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-16 至 2001-02-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6152993
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; cerebral ischemia /hypoxia; electroencephalography; human subject; noninvasive diagnosis; patient monitoring device; stroke

The recent use of thrombolytic drugs to effectively treat ischemic stroke marks a milestone in the campaign against this common neurological disease. Although a significant advancement, this treatment is not suitable for all patients, such as those who are experiencing a hemorrhagic stroke or those receiving treatment more than three hours after stroke onset. Hospital staff can use computed tomography (CT) scans to easily rule out hemorrhages. More difficult, however, is estimating the therapeutic window of time. Late treatment still brings the hemorrhagic risk of thrombolytic treatment, but it faces an increasingly uncertain state of the neural tissue. A rapid, inexpensive, and noninvasive cerebral monitoring technique could help hospital staff to determine neural-tissue state as well as to assess the effectiveness of thrombolytic treatment. In this Phase I project, we will use dense-array electroencephalography (EEG) to collect near-continuous, stroke-related EEG so that we can evaluate the ongoing pathophysiological evolution of the ischemic tissue. Spectral and coherence analyses of the raw EEG data will enable us to characterize EEG changes in these records. The results from this work will go toward the development of a rapid, inexpensive, noninvasive, accurate stroke-monitoring device based on dense-array EEG. PROPOSED COMMERCIAL APPLICATIONS: EEG is highly sensitive to stroke-related pathophysiology. Its use in surgical monitoring is well known; however, its potential as a practical, inexpensive stroke-monitoring technology heretofore has been overlooked. If we can demonstrate that stroke-related EEG changes can help inform treatment decisions, every hospital and clinic treating acute stroke would require this monitoring system -an obviously lucrative prospect, with a worldwide market potential approaching $1 billion.

最近使用溶栓药有效治疗缺血性中风标志着反对这种常见神经系统疾病的里程碑。尽管有重大的进步，但这种治疗方法并不适合所有患者，例如那些患有出血性中风的患者或中风发作后三个多小时以上接受治疗的患者。医院工作人员可以使用计算机断层扫描（CT）扫描轻松排除出血。但是，更困难的是估计时间窗口。晚期治疗仍然带来溶栓治疗的出血风险，但它面临着越来越不确定的神经组织状态。快速，廉价且无创的脑监测技术可以帮助医院工作人员确定神经组织状态，并评估血栓溶解治疗的有效性。在此I阶段项目中，我们将使用密集的阵列脑电图（EEG）收集与中风相关的近乎连续的脑电图，以便我们可以评估缺血组织的持续病理生理演化。原始脑电图数据的光谱和相干分析将使我们能够表征这些记录中的脑电图变化。这项工作的结果将用于开发基于密集的阵列EEG的快速，廉价，无创，准确的中风监测装置。提出的商业应用：EEG对中风相关的病理生理学高度敏感。它在手术监测中的使用是众所周知的。但是，它作为一种实用，廉价的中风监控技术的潜力被忽略了。如果我们能够证明与中风相关的脑电图变化可以帮助治疗决策，那么每个医院和诊所治疗急性中风都需要这种监测系统 - 显然是有利可图的前景，全球市场潜力接近10亿美元。