Exploring DNA methylation as a mechanism for long-term memory for fear extinction

探索 DNA 甲基化作为恐惧消退长期记忆的机制

• 批准号: nhmrc : 1023127
• 负责人: A/Pr Timothy Bredy
• 金额: $ 27.69万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-dna-methylation-fear-extinction/110246
• 关键词: Exploring; DNA; methylation; mechanism; long

Traumatic experiences are well remembered. In some cases, fear-related memories become debilitating and require therapeutic intervention to diminish the impact of these kinds of memories on daily living. Such therapies engage a process of inhibitory learning called fear extinction. Since anxiety disorders are particularly sensitive to relapse even after extensive exposure therapy, a deeper understanding of the extinction process is crucial if we are to develop more effective treatment protocols for a variety of anxiety disorders.

创伤性的经历被铭记。在某些情况下，与恐惧有关的记忆会变得衰弱，需要治疗干预来减少这些记忆对日常生活的影响。这种疗法涉及一种被称为恐惧消退的抑制性学习过程。由于焦虑症对复发特别敏感，即使在广泛的暴露治疗后，如果我们要为各种焦虑症制定更有效的治疗方案，对消退过程的更深入了解至关重要。