MicroRNA regulation of fear-related memory

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Emotionally traumatic experiences are well remembered and, in some instances, frequent reminders of these events can lead to the development of fear-related anxiety disorders such as phobia or post-traumatic stress disorder (PTSD). The experiments outlined in this proposal will examine how a novel epigenetic mechanism of gene regulation contributes to the transition from the retrieval of a fear memory to its inhibition through a process called extinction.