MicroRNA regulation of fear-related memory

MicroRNA对恐惧相关记忆的调节

• 批准号: nhmrc : 1042051
• 负责人: A/Pr Timothy Bredy
• 金额: $ 32.69万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/microrna-regulation-fear-related-memory/111431
• 关键词: MicroRNA; regulation; fear; related; memory

Emotionally traumatic experiences are well remembered and, in some instances, frequent reminders of these events can lead to the development of fear-related anxiety disorders such as phobia or post-traumatic stress disorder (PTSD). The experiments outlined in this proposal will examine how a novel epigenetic mechanism of gene regulation contributes to the transition from the retrieval of a fear memory to its inhibition through a process called extinction.

创伤性经历会被很好地记住，在某些情况下，频繁地提醒这些事件可能会导致与恐惧有关的焦虑症，如恐惧症或创伤后应激障碍（PTSD）的发展。本提案中概述的实验将研究一种新的基因调控表观遗传机制如何通过一个称为灭绝的过程，促进从恐惧记忆的恢复到抑制的过渡。