Transgenerational impacts of paternal stress on offspring mental health: Epigenetic mechanisms and therapeutic interventions

父亲压力对后代心理健康的跨代影响：表观遗传机制和治疗干预

• 批准号: nhmrc : 1083468
• 负责人: A/Pr Timothy Bredy
• 金额: $ 38.2万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transgenerational-impacts-paternal-therapeutic-interventions/518935
• 关键词: Transgenerational; impacts; paternal; stress; offspring

We are following up the extraordinary, almost ‘Lamarckian’, discovery that environmental influences on fathers can affect their offspring via ‘epigenetic’ changes to the sperm. We will explore mechanisms whereby increased levels of paternal stress can cause behavioural changes in the offspring, which are relevant to depression and anxiety disorders, and how positive environmental factors, including physical activity, may induce beneficial effects. This will have major public health implications.

我们正在跟进一个非同寻常的、几乎是“拉马克式”的发现，即环境对父亲的影响可以通过精子的“表观遗传”变化影响他们的后代。我们将探讨父亲压力水平的增加可能导致后代行为变化的机制，这些行为变化与抑郁症和焦虑症有关，以及积极的环境因素，包括身体活动，可能会产生有益的影响。这将对公共卫生产生重大影响。