Novel DNA modifications underlying sex differences in fear-related learning and memory

恐惧相关学习和记忆中性别差异背后的新 DNA 修饰

• 批准号: nhmrc : 1145172
• 负责人: A/Pr Timothy Bredy
• 金额: $ 35.97万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-dna-modifications-learning-memory/1320379
• 关键词: Novel; DNA; modifications; underlying; sex

Women are at increased risk of developing fear-related anxiety disorders. We have recently discovered that there sex-specific regulatory mechanisms in the brain that are associated with differences in the control of fear. In this proposal, we will determine whether novel DNA modifications in the female brain are responsible for establishing sex differences in brain states that make the brain more or less responsive to fear-related learning.

女性患与恐惧有关的焦虑症的风险增加。我们最近发现，大脑中存在性别特异性的调节机制，与恐惧控制的差异有关。在这项提案中，我们将确定女性大脑中新的DNA修饰是否负责建立大脑状态的性别差异，使大脑对恐惧相关学习的反应或多或少。