Cracking the epigenetic code: understanding the mechanisms of memory associated with anxiety-related disorders and their treatment

破解表观遗传密码：了解与焦虑相关疾病相关的记忆机制及其治疗

• 批准号: nhmrc : GNT1135896
• 负责人: A/Pr Timothy Bredy
• 金额: $ 64.02万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cracking-epigenetic-code-disorders-treatment/1348006
• 关键词: Cracking; epigenetic; code; understanding; mechanisms

The primary goal of my research programme is to elucidate how the epigenome coordinates experience-dependent gene expression underlying associative learning and memory using paradigms relevant for understanding fear-related anxiety disorders. My research on DNA modifications and newly emerging findings in the realm of RNA biology is changing the way we think about gene-environment interactions, the broader impact of which will most certainly continue to be felt for years to come.

我的研究计划的主要目标是阐明表观基因组是如何利用与理解恐惧相关焦虑症相关的范式来协调联想学习和记忆背后的经验依赖基因表达的。我对DNA修饰和RNA生物学领域新发现的研究正在改变我们思考基因与环境相互作用的方式，其更广泛的影响几乎肯定会在未来几年继续感受到。