Epigenetic impacts of paternal experience on offspring anxiety and cognition: Molecular mediators and therapeutic targets

父亲经历对后代焦虑和认知的表观遗传影响：分子介质和治疗靶点

• 批准号: nhmrc : 1138321
• 负责人: A/Pr Timothy Bredy
• 金额: $ 46.06万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-impacts-paternal-therapeutic-targets/1318714
• 关键词: Epigenetic; impacts; paternal; experience; offspring

Stress and physical activity are two of the major lifestyle factors impacting on human health, including brain disorders. We have recently discovered that stress and exercise in male mice can impact the phenotype of offspring. We will study molecules in the sperm of these fathers, and in the brains of offspring to understand the mechanisms involved. There is evidence that lifestyle factors in men prior to conception impact on their children and this research has major public health implications.

压力和体力活动是影响人类健康的两个主要生活方式因素，包括大脑疾病。我们最近发现，雄性小鼠的压力和运动可以影响后代的表型。我们将研究这些父亲精子中的分子，以及后代大脑中的分子，以了解其中的机制。有证据表明，男性在怀孕前的生活方式因素会影响他们的孩子，这项研究具有重大的公共卫生意义。