Center for Molecular & Cellular Studies of Ped Disease

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PrincipInavl estigator/PrDogirreacmt(oLarst, first, middle). FRANK, Michael M. DESCRIPTION: State the application's broad, long-term objectives and specific aims, making reference to the health relatedness of the project. Describe concisely the research design and methods for achieving these goals. Avoid summaries of past accomplishments and the use of the first person. This abstract is meant to serve as a succinct and accurate description of the proposed work when separated from the application. If the application is funded, this description, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT :XCEED THE SPACE PROVIDED. lack of understanding of the processes underlying pediatric illnesses and their appropriate therapy inflicts a heavy burden on children and their families. Our Child Health Research Career Development Award (CHRCDA) program will address this issue through training and mentoring young pediatric investigators. The Principal Investigator will be Dr. Michael M. Frank, Chair of the Department of Pediatrics, who has had a long successful career in training and mentoring. The day-to-day direction of the program will be provided by the Program Director, Dr. Page A. W. Anderson, Vice Chair of Research for the Department of Pediatrics. Dr. Delbert R. Wigfall, Associate Professor of Pediatrics, Associate Dean and Director of the Duke Institutional Multicultural Resource Center, will be our Minority Recruitment Advisor. The program will have two committees. The Internal Advisory Committee, Chaired by Dr. Frank, is made up of members of our Department and Institution who are experienced investigators and mentors with leadership roles in our Institution. A subcommittee will assess and rank potential trainees. Recruitment of trainees from under-represented minorities will be a focus of our program. Dr. Frank will select the trainees. The Committee will interview the trainees and mentors on a regular basis. They, in concert with Drs. Frank and Anderson, will initiate any needed actions to support the progress of the trainees through the program. The External Advisory Board, made up of internationally recognized scientists and pediatricians from across the United States, will review on an annual basis the accomplishment of the program goals, the progress of the trainees and advise the Principal investigator. Four trainees will be admitted the first year and four supported each year of the program. The training period will last from two-to-five years. The trainees' will dedicate over 75% of their time to the training program. The mentors will be selected based on their success in mentoring, the pediatric relevance of their research, leadership roles, and NIH funding. The trainees will be required to take courses in Responsible Conduct of Research, grant and manuscript writing, and core courses that include an Introduction to Statistics, Analysis of Genetic Data, and Molecular Genetics of Human Disease. The trainees will be required to give oral presentations to develop their communication skills. We are committed to recruiting these trainees to our Department faculty. Our previous success in training and developing the scientific careers of junior supports the long-term goal of this CHRCDA to develop successful academic pediatric scientists. PERFORMANCE SITE ========================================Section End===========================================