FAMILIAL FACTORS IN BARRETT'S ESOPHAGUS

巴雷特食管的家族因素

• 批准号: 6899262
• 负责人: AMITABH CHAK
• 金额: $ 13.24万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6899262
• 关键词: Barretts esophagus; adenocarcinoma; endoscopy; family genetics; genetic susceptibility; human subject; longitudinal human study; patient oriented research

DESCRIPTION (provided by applicant) Advances in basic sciences often translate into an increased understanding of disease processes. Similarly, advances in endoscopic engineering also produce new technology with novel applications in clinical gastroenterology. I believe that patient-oriented researchers in gastrointestinal diseases and gastrointestinal endoscopy must translate advances in basic sciences and engineering technology to improved methods for patient care. Using my previous experience in basic research and training in advanced endoscopy, I have initiated and successfully implemented investigations that address this goal. My research objectives have been furthered by the opportunity to mentor several advanced gastroenterology fellows in the performance of specialized endoscopic procedures and patient-oriented research projects. These trainees are now productive clinical investigators in the field of gastrointestinal endoscopy. Protected time provided by this award will permit me to develop a meaningful research program that focuses on applying new endoscopic techniques and advances in human genetics to the evaluation of Barrett's esophagus and esophageal adenocarcinoma. The award will also further my education in two areas in which it is slightly deficient, viz., biostatistics and human genetics. Educational courses in these subjects and collaborations with experts in these fields will strengthen the development of my research program. Lastly, the award will allow me to teach advanced endoscopy to new trainees and mentor them in the development of their own research projects within my program. Esophageal adenocarcinoma is associated with a very poor prognosis. More effective screening, surveillance, and treatment strategies are required. The aim of the current proposal is to identify familial factors involved in the development of Barrett's esophagus and esophageal adenocarcinoma. The ultimate goal of this research program is to help identify the heritable genetic mutation(s) that determine susceptibility to Barrett's esophagus in order to improve screening and surveillance strategies for this disease.

描述(由申请人提供) 基础科学的进步往往转化为对 疾病过程。同样，内窥镜工程的进步也产生了 新技术在临床胃肠病学中的新应用。我相信 以患者为中心的胃肠道疾病研究人员 胃肠道内窥镜检查必须将基础科学和 从工程技术到改进病人护理方法。用我以前的 在基础研究和高级内窥镜培训方面的经验，我有 发起并成功实施了针对这一目标的调查。 我的研究目标因为有机会指导了几个 高级胃肠病研究员在专业内窥镜检查中的表现 程序和以病人为中心的研究项目。这些实习生现在 胃肠道内窥镜检查领域富有成效的临床研究人员。 这个奖项提供的保护时间将允许我开发一个有意义的 专注于应用新的内窥镜技术和 人类遗传学在Barrett‘s食道和食道疾病诊断中的研究进展 食管腺癌。该奖项还将使我在两年内继续深造 它略有不足的领域，即生物统计学和人类 遗传学。这些学科的教育课程以及与专家的合作 在这些领域将加强我的研究计划的发展。最后， 该奖项将允许我向新学员和导师教授先进的内窥镜检查 他们在我的项目中发展自己的研究项目。 食管腺癌与预后非常差有关。更多 需要有效的筛查、监测和治疗策略。这个 目前这项建议的目的是确定家庭因素涉及的 Barrett‘s食道和食管腺癌的发生发展。终极的 这项研究计划的目标是帮助识别可遗传的基因 突变(S)，决定对巴雷特食道的易感性，以便 完善该病的筛查和监测策略。